Reaction: Ezetimibe to 1 product
Ezetimibe is converted to Ezetimibe glucuronide by UDP-glucuronosyltransferase 1A1, UDP-glucuronosyltransferase 1A3, and UDP-glucuronosyltransferase 2B15.
- Reaction
- Direction
- Activity
- active
- Comments
- The 4-hydroxyphenyl group of ezetimibe is glucuronidated. Ezetimibe-glucuronide accounts for the majority (80–90%) of total ezetimibe concentrations measured in human plasma, and it is reported to retain some pharmacological activity in inhibiting intestinal cholesterol absorption with less potency compared to the parent compound.
What you can answer from here — as of June 11, 2018
3EnzymesEach linked to its target cardListed above
Which other drugs are metabolised by UDP-glucuronosyltransferase 1A1, UDP-glucuronosyltransferase 1A3, and UDP-glucuronosyltransferase 2B15, and which of those pairings are clinically significant?
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