UDP-glucuronosyltransferase 2B15

BE0004696ProteinHumansUGT2B15

UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:16595710, PubMed:18719240, PubMed:23288867,... It is acted on by 21 drugs in DrugBank.

Gene name
UGT2B15
UniProtKB entry
P54855Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
530 residues · 61,036 Da
Also known as
2.4.1.17 · HLUG4 · UDP-glucuronosyltransferase 2B8 · UDPGT 2B15 · UDPGT 2B8

Resolves to

Protein
UniProtP54855UniProt nameUDB15_HUMAN
Gene
HGNCHGNC:12546NCBI Gene7366GeneCardsUGT2B15
Pharmacology
KEGGhsa:7366
Structure
PDB6IPBPDB7CJX
Drugs

What you can answer from here — as of September 07, 2019

21DrugsApproved to experimental, with action, bond type and pharmacological action
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20Metabolic reactionsDrug transformations it catalyses, substrate to product
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1GO termFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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31+ReferencesStructured and connected to the statements they support
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Which approved drugs act on UDP-glucuronosyltransferase 2B15, how selective are they, and which programs against it are still in active trials?

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