Reaction: Hydrocodone to 1 product

Reaction
Hydrocodone
DB00956
Hydromorphone
DB00327
Reaction type
O-demethylation
Direction
Not Available
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Cone EJ, Darwin WD, Gorodetzky CW, Tan T: Comparative metabolism of hydrocodone in man, rat, guinea pig, rabbit, and dog. Drug Metab Dispos. 1978 Jul-Aug;6(4):488-93. [Article]
  2. Hutchinson MR, Menelaou A, Foster DJ, Coller JK, Somogyi AA: CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes. Br J Clin Pharmacol. 2004 Mar;57(3):287-97. [Article]
  3. FDA Label: Hydrocodone Tab ER [Link]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 2D6Not AvailableNot Availableconfirmed
Cytochrome P450 2B6Not AvailableNot Availableconfirmed
Cytochrome P450 2C19Not AvailableNot Availableimplied