Reaction: Mirabegron to 1 product

Reaction
Reaction type
N-oxidation; glucuronidation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Takusagawa S, van Lier JJ, Suzuki K, Nagata M, Meijer J, Krauwinkel W, Schaddelee M, Sekiguchi M, Miyashita A, Iwatsubo T, van Gelderen M, Usui T: Absorption, metabolism and excretion of [(14)C]mirabegron (YM178), a potent and selective beta(3)-adrenoceptor agonist, after oral administration to healthy male volunteers. Drug Metab Dispos. 2012 Apr;40(4):815-24. doi: 10.1124/dmd.111.043588. Epub 2012 Jan 23. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 3A4Not AvailableNot Availableimplied
Cytochrome P450 2D6Not AvailableNot Availableimplied
UDP-glucuronosyltransferase 2B7Not AvailableNot Availableimplied
UDP-glucuronosyltransferase 1-3Not AvailableNot Availableimplied
UDP-glucuronosyltransferase 1-8Not AvailableNot Availableimplied