Ephedrine sulfateProduct ingredient for Ephedrine
- Name
- Ephedrine sulfate
- Drug Entry
- Ephedrine
Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with pseudoephedrine.5 Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepinephrine from sympathetic neurons, inhibiting norepinephrine reuptake and displacing more norepinephrine from storage vesicles.4,8 Ephedrine is used for its vasoconstrictive, positive chronotropic, and positive inotropic effects.8 Ephedrine and phenylephrine are still used to treat hypotension, but their use in other indications has decreased due to the development of more selective adrenergic agonists.6,7,9 Ephedrine was granted a type 7 FDA Approval on 29 April 2016.9
- Accession Number
- DBSALT001503
- Structure
- Synonyms
- Not Available
- UNII
- U6X61U5ZEG
- CAS Number
- 134-72-5
- Weight
- Average: 428.54
Monoisotopic: 428.198107932 - Chemical Formula
- C20H32N2O6S
- InChI Key
- CAVQBDOACNULDN-KHFUBBAMSA-N
- InChI
- InChI=1S/2C10H15NO.H2O4S/c2*1-8(11-2)10(12)9-6-4-3-5-7-9;1-5(2,3)4/h2*3-8,10-12H,1-2H3;(H2,1,2,3,4)/t2*8-,10-;/m00./s1
- IUPAC Name
- bis((1R,2S)-2-(methylamino)-1-phenylpropan-1-ol); sulfuric acid
- SMILES
- OS(O)(=O)=O.CN[C@@H](C)[C@H](O)C1=CC=CC=C1.CN[C@@H](C)[C@H](O)C1=CC=CC=C1
- External Links
- ChemSpider
- 4514262
- ChEMBL
- CHEMBL1523964
- Wikipedia
- Ephedrine
- Predicted Properties
Property Value Source Water Solubility 8.26 mg/mL ALOGPS logP 1 ALOGPS logP 1.32 Chemaxon logS -1.3 ALOGPS pKa (Strongest Acidic) 13.89 Chemaxon pKa (Strongest Basic) 9.52 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 32.26 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 49.69 m3·mol-1 Chemaxon Polarizability 18.93 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon