Glycopyrronium tosylateProduct ingredient for Glycopyrronium
- Name
- Glycopyrronium tosylate
- Drug Entry
- Glycopyrronium
Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers.15 They are both quaternary ammonium compounds and long acting muscarinic antagonists.15 It is one of the most commonly prescribed anticholinergic medications.2,3 Early research into glycopyrronium use was for its indication as an adjunct therapy in the treatment of peptic ulcers.9,10 Later research, taking advantage of the systemic distribution of muscarinic receptors through the body, found that glycopyrronium could also be used for reducing sweat gland,12 oral,18 airway, and gastric secretions;17 as well as reducing cardiac inhibitory reflexes;17 and reducing bronchoconstriction in COPD.13 Glycopyrronium is commonly prescribed as a first line treatment for a wide variety indications and is considered to have a wider therapeutic window than tiotropium.8
Glycopyrronium was originally granted FDA approval on 11 August 1961.10
- Accession Number
- DBSALT002800
- Structure
Structure for Glycopyrronium tosylate (DBSALT002800)
- Synonyms
- Glycopyrronium tosylate monohydrate
- UNII
- 1PVF6JLU7B
- CAS Number
- 1624259-25-1
- Weight
- Average: 507.64
Monoisotopic: 507.229073709 - Chemical Formula
- C26H37NO7S
- InChI Key
- UOWOLENSDISMPG-UHFFFAOYSA-M
- InChI
- InChI=1S/C19H28NO3.C7H8O3S.H2O/c1-20(2)13-12-17(14-20)23-18(21)19(22,16-10-6-7-11-16)15-8-4-3-5-9-15;1-6-2-4-7(5-3-6)11(8,9)10;/h3-5,8-9,16-17,22H,6-7,10-14H2,1-2H3;2-5H,1H3,(H,8,9,10);1H2/q+1;;/p-1
- IUPAC Name
- 3-[(2-cyclopentyl-2-hydroxy-2-phenylacetyl)oxy]-1,1-dimethylpyrrolidin-1-ium 4-methylbenzene-1-sulfonate hydrate
- SMILES
- O.CC1=CC=C(C=C1)S([O-])(=O)=O.C[N+]1(C)CCC(C1)OC(=O)C(O)(C1CCCC1)C1=CC=CC=C1
- External Links
- ChemSpider
- 58902513
- ChEMBL
- CHEMBL3707243
- Predicted Properties
Property Value Source Water Solubility 0.000569 mg/mL ALOGPS logP -0.16 ALOGPS logP -1.4 Chemaxon logS -5.9 ALOGPS pKa (Strongest Acidic) 11.53 Chemaxon pKa (Strongest Basic) -4.3 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 46.53 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 101.08 m3·mol-1 Chemaxon Polarizability 35.84 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon