Lactitol monohydrateProduct ingredient for Lactitol
- Name
- Lactitol monohydrate
- Drug Entry
- Lactitol
Lactitol, also known as 4-β-D-galactopyranosyl-D-glucitol, is a sugar alcohol synthesized from lactose.3 It is used in food manufacturing as a nutritive sweetener and is approximately 35% as sweet as table sugar (i.e. sucrose).1 Clinically, lactitol has been investigated for use as an osmotic laxative and, along with other non-absorbable disaccharides such as lactulose, in the treatment of hepatic encephalopathy in patients with cirrhosis.2,3
Pizensy, an oral lactitol powder for solution, was approved by the FDA for use in chronic idiopathic constipation in February 2020.4
- Accession Number
- DBSALT002935
- Structure
Structure for Lactitol monohydrate (DBSALT002935)
- Synonyms
- 4-O-beta-D-Galactopyranosyl-D-glucitol monohydrate / Lactitol hydrate / Lactitol monohydrate
- UNII
- UH2K6W1Y64
- CAS Number
- 81025-04-9
- Weight
- Average: 362.328
Monoisotopic: 362.142426277 - Chemical Formula
- C12H26O12
- InChI Key
- LXMBXZRLTPSWCR-XBLONOLSSA-N
- InChI
- InChI=1S/C12H24O11.H2O/c13-1-4(16)7(18)11(5(17)2-14)23-12-10(21)9(20)8(19)6(3-15)22-12;/h4-21H,1-3H2;1H2/t4-,5+,6+,7+,8-,9-,10+,11+,12-;/m0./s1
- IUPAC Name
- (2S,3R,4R,5R)-4-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}hexane-1,2,3,5,6-pentol hydrate
- SMILES
- O.OC[C@H](O)[C@@H](O)[C@H](O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)[C@H](O)CO
- External Links
- ChemSpider
- 2327416
- ChEMBL
- CHEMBL1200429
- Wikipedia
- Lactitol
- Predicted Properties
Property Value Source Water Solubility 377.0 mg/mL ALOGPS logP -3.2 ALOGPS logP -5.5 Chemaxon logS 0.04 ALOGPS pKa (Strongest Acidic) 12.1 Chemaxon pKa (Strongest Basic) -3 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 11 Chemaxon Hydrogen Donor Count 9 Chemaxon Polar Surface Area 200.53 Å2 Chemaxon Rotatable Bond Count 8 Chemaxon Refractivity 70.82 m3·mol-1 Chemaxon Polarizability 31.73 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon