Lactulose is a disaccharide derivative of lactose used to treat constipation and portal systemic encephalopathy.
- Brand Names
- Constulose, Enulose, Generlac, Kristalose
- Generic Name
- DrugBank Accession Number
Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).Label,3,4 Despite being first synthesized in 19291, investigations regarding its possible use as a laxative for the treatment of chronic constipation did not occur until the 1960s and its first clinical use for treating PSE was not until 1966.4
Nevertheless, although lactulose received formal FDA approval in 1977 and has since become a readily available generic and brand-name non-prescription medication listed on the World Health Organization's List of Essential Medicines as one of the most effective and safe medicines employed in a health system5, data regarding its optimal place in therapy is often ambiguous.4
Especially considering the use of lactulose as a laxative is typically only considered after lifestyle and dietary modifications fail and the fact that lactulose therapy cannot be ethically withheld from patients diagnosed with PSE in a placebo study, the substance may just be one of many options available for treating constipation and its efficacy in managing PSE may never be formally confirmed or refuted via clinical investigation.4
- Small Molecule
- Average: 342.2965
- Chemical Formula
Additionally, lactulose is also employed as an adjunct to protein restriction and supportive therapy for the prevention and treatment of portal-systemic encephalopathy (PSE), including both the hepatic pre-coma and coma variations.Label,3,4 In particular, lactulose solution has been effective at managing PSE resulting from surgical portacaval shunts or from chronic hepatic diseases like cirrhosis.3
Moreover, there have also been studies demonstrating the capacity for lactulose to minimize the formation of gallstones and even some investigations regarding the experimental use of the agent in developing novel anticancer agents owing to its ability to bind galactin carbohydrates involved in various tumor progressions 4.Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.
- Associated Conditions
- Contraindications & Blackbox Warnings
- Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.
Lactulose formulations are most commonly administered via the oral route or the rectal route.4 Consequently, because the substance experiences minimal absorption by the gut it typically remains localized in the gastrointestinal tract environment and ultimately demonstrates almost all of its pharmacologic effects within the gut.Label,3,4 In particular, as lactulose elicits its laxative effects in enhancing stool amounts and softening stool, such biochemical and physiologic activities can cause increased bowel sounds (borborygmi), a feeling of bloatedness, belching, frequent flatus, and diarrhea.Label,3,4
- Mechanism of action
Lactulose is a synthetic disaccharide derivative of lactose that consists of one molecule of galactose and one molecule of fructose.Label,3,4 Saccharolytic bacteria present in the large intestine subsequently break the substance down into organic acids like lactic acid and small amounts of formic and acetic acids.Label,3,4 Such resultant volatile fatty acid metabolites, in combination with hydrogen and methane that is also generated consequently enhance intraluminal gas formation, peristaltic gut motility, and elicit an osmotic effect that facilitates an increase in the water content of stool as well as associated stool softening.Label,3,4 All of these actions ultimately assist in facilitating and increasing the frequency of bowel movements in patients experiencing constipation, although it may take 24 to 48 hours after using the medication for this laxative effect to become evident.Label,3,4
At the same time, the formation of such acids via the metabolism of lactulose by colonic bacteria also acidifies the contents of the colon, thereby contributing to the treatment of portal-systemic encephalopathy (PSE).Label,3,4 As one of the principal features of PSE involves the accumulation of nitrogenous waste products like ammonia in the systemic circulation, a state in which the colonic contents become more acidic than blood allows ammonia in the circulation to diffuse into the colon.Label,3,4. Furthermore, ammonia that diffuses into the acidic colon is ionized to ammonium ions that are incapable of being absorbed back into the blood.Label,3,4 These effects, combined with the laxative action of lactulose facilitates the excretion of excess ammonia.Label,3,4 And finally, it is also believed that an acidic colonic environment results in the elimination of urease-producing bacteria that contribute to the formation of ammonia while surviving colonic bacteria use up any trapped ammonia in the colon as a source of nitrogen for protein synthesis.4
Target Actions Organism UEvolved beta-galactosidase subunit alphaother Escherichia coli (strain K12)
After administration by the oral route, less than 3% of the given dose of lactulose solution is absorbed by the small intestine.3 The remaining unabsorbed lactulose reaches the large intestine where it is metabolized - but even then, negligible quantities of unchanged lactulose or its metabolites are absorbed across the colon.3,4
- Volume of distribution
Negligible amounts of lactulose - metabolized or non-metabolized - are absorbed into the body.Label,3,4. Most lactulose that is administered subsequently remains predominantly around the gastrointestinal tract area.
- Protein binding
Negligible amounts of lactulose - metabolized or non-metabolized - are absorbed into the body.Label,3,4. Regardless, data regarding the protein binding of lactulose is not readily available or accessible.
Lactulose is essentially only metabolized in the colon by saccharolytic bacteria that are present there.Label,3,4 In particular, the substance is broken down into lactic acid and small amounts of acetic and formic acid.Label,3,4 Specific examples of bacteria that normally inhabit the large intestine that are capable of lactulose metabolism include Lactobacilli, Bacteroides, Escherichia coli, and Clostridia.3
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- Route of elimination
The renal excretion of any lactulose that manages to be absorbed into the circulation has been determined to be 3% or less and is generally complete within 24 hours.Label Any unabsorbed lactulose is largely excreted with stool.Label,3,4
The data regarding the half-life of lactulose is not readily available or accessible.
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.
Considering the use of lactulose during pregnancy in humans has not been formally investigated, the agent should only be used during pregnancy only when clearly needed.Label,3,4 Similarly, it is unknown whether lactulose is distributed into human breastmilk.Label,3,4 Use of the medication in nursing women should subsequently be undertaken with caution.Label,3,4
Data regarding the safety and efficacy of using lactulose in children for the treatment of chronic constipation or portal-systemic encephalopathy (PSE) is either very limited or yet to be established.Label,3,4
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Acenocoumarol The risk or severity of bleeding can be increased when Lactulose is combined with Acenocoumarol. Acetazolamide The risk or severity of adverse effects can be increased when Acetazolamide is combined with Lactulose. Acetyl sulfisoxazole The therapeutic efficacy of Lactulose can be decreased when used in combination with Acetyl sulfisoxazole. Aclidinium The therapeutic efficacy of Lactulose can be decreased when used in combination with Aclidinium. Alfentanil The therapeutic efficacy of Lactulose can be decreased when used in combination with Alfentanil. Alloin The risk or severity of adverse effects can be increased when Lactulose is combined with Alloin. Almasilate The therapeutic efficacy of Lactulose can be decreased when used in combination with Almasilate. Aluminium phosphate The therapeutic efficacy of Lactulose can be decreased when used in combination with Aluminium phosphate. Aluminum hydroxide The therapeutic efficacy of Lactulose can be decreased when used in combination with Aluminum hydroxide. Amantadine The therapeutic efficacy of Lactulose can be decreased when used in combination with Amantadine.Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more
- Food Interactions
- Drink plenty of fluids. This drug may cause fluid loss.
- Take with or without food.
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- International/Other Brands
- Bifiteral (Abbott) / Cephulac / Cholac (Alra) / Chronulac / Constilac (Alra) / Laevolac (Roche)
- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Lactulose Solution 10 g/15mL Oral; Rectal ANI Pharmaceuticals Inc. 2008-12-16 2008-12-16 Lactulose Solution 10 g/15mL Oral ANI Pharmaceuticals Inc. 2009-05-21 2009-05-21
- Generic Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Constulose Solution 10 g/15mL Oral Actavis Mid Atlantic LLC, 2007-01-03 2012-02-29 Constulose Solution 10 g/15mL Oral A-S Medication Solutions 2011-02-28 Not applicable Constulose Solution 10 g/15mL Oral Actavis Pharma, Inc. 2011-02-28 Not applicable Enulose Solution 10 g/15mL Oral; Rectal bryant ranch prepack 2011-02-28 Not applicable Enulose Solution 10 g/15mL Oral; Rectal Actavis Pharma, Inc. 2011-02-28 Not applicable Enulose Liquid 10 g/15mL Oral; Rectal Actavis Pharma, LLC 1990-10-31 2012-08-31 Generlac Solution 10 g/15mL Oral; Rectal Morton Grove Pharmaceuticals, Inc. 1996-10-31 Not applicable Kristalose Powder, for solution 20 g/20g Oral Jones Contract Packaging Services 2018-01-24 2018-08-20 Kristalose Powder, for solution 10 g/10g Oral Cumberland Pharmaceuticals Inc. 2012-01-20 Not applicable Kristalose Powder, for solution 10 g/10g Oral Jones Contract Packaging Services 2018-01-24 2018-08-20
- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image ANPROLAC SOLUTION 670mg/ml Solution Oral MALAYSIAN PHARMACEUTICAL INDUSTRIES SDN. BHD. 2020-09-08 Not applicable Apo-lactulose Solution 667 mg / mL Oral Bajaj Medical, Llc 2001-02-19 Not applicable AVELAC ORAL SOLUTION 667mg/ml Solution Oral APEX PHARMACY MARKETING SDN. BHD. 2020-09-08 Not applicable Cephulac Syr 667mg/ml Syrup 667 mg / mL Oral Hoechst Marion Roussel 1995-12-31 1998-08-12 Chronulac Syr Syrup 667 mg Oral Merrell Pharms Inc., Division Of Merrell Dow (Can) 1977-12-31 1996-09-09 Chronulac Syr 667mg/ml Syrup 667 mg / mL Oral Hoechst Marion Roussel 1996-12-31 1998-08-12 Comalose R Sirop 10gm/15ml Syrup 10 g / 15 mL Oral; Rectal Rougier Pharma Division Of Ratiopharm Inc 1987-12-31 1999-09-27 DHACTULOSE SYRUP Syrup Oral ACTAVIS SDN. BHD. 2020-09-08 Not applicable Duphalac Powder 95 g / 100 g Oral Solvay Pharma Inc 1997-11-27 2001-02-12 Duphalac Dry Powder 950 mg / g Oral Solvay Pharma Inc 1996-07-23 1998-08-04
- ATC Codes
- A06AD61 — Lactulose, combinations
- A06AD — Osmotically acting laxatives
- A06A — DRUGS FOR CONSTIPATION
- A06 — DRUGS FOR CONSTIPATION
- A — ALIMENTARY TRACT AND METABOLISM
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- This compound belongs to the class of organic compounds known as o-glycosyl compounds. These are glycoside in which a sugar group is bonded through one carbon to another group via a O-glycosidic bond.
- Organic compounds
- Super Class
- Organic oxygen compounds
- Organooxygen compounds
- Sub Class
- Carbohydrates and carbohydrate conjugates
- Direct Parent
- O-glycosyl compounds
- Alternative Parents
- Disaccharides / C-glycosyl compounds / Oxanes / Tetrahydrofurans / Secondary alcohols / Hemiacetals / Polyols / Oxacyclic compounds / Acetals / Primary alcohols / Hydrocarbon derivatives show 1 more
- Acetal / Alcohol / Aliphatic heteromonocyclic compound / C-glycosyl compound / Disaccharide / Hemiacetal / Hydrocarbon derivative / O-glycosyl compound / Organoheterocyclic compound / Oxacycle / Oxane / Polyol / Primary alcohol / Secondary alcohol / Tetrahydrofuran show 5 more
- Molecular Framework
- Aliphatic heteromonocyclic compounds
- External Descriptors
- glycosylfructose (CHEBI:6359)
- Affected organisms
- Humans and other mammals
- CAS number
- InChI Key
- IUPAC Name
- Synthesis Reference
Renato Carobbi, Franco Innocenti, "Process for preparing high-purity lactulose syrup and the syrup obtained." U.S. Patent US4978397, issued April, 1961.US4978397
- General References
- Schumann C: Medical, nutritional and technological properties of lactulose. An update. Eur J Nutr. 2002 Nov;41 Suppl 1:I17-25. doi: 10.1007/s00394-002-1103-6. [Article]
- Canadian Pharmacists Association (2019). Compendium of Pharmaceuticals and Specialties. Canadian Pharmacists Association.
- Lactulose Canadian Product Monograph [Link]
- NCBI StatPearls [Internet]: Lactulose [Link]
- WHO Model List of Essential Medicines 19th List (April 2015 - Amended November 2015) [Link]
- DailyMed: lactulose solution [Link]
- Human Metabolome Database
- KEGG Drug
- KEGG Compound
- PubChem Compound
- PubChem Substance
- RxList Drug Page
- Drugs.com Drug Page
- PDRhealth Drug Page
- PDB Entries
- 3w9t / 6b8k / 6b94 / 6nwm
- FDA label
- Download (151 KB)
- Download (73.6 KB)
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Not Available Osteopenia (Disorder) 1 4 Completed Basic Science Motility Disorder of Intestine / Ondansetron / Small Bowel Water 1 4 Completed Basic Science Type 2 Diabetes Mellitus 1 4 Completed Prevention Hepatic Encephalopathy (HE) 1 4 Completed Treatment Cirrhosis of the Liver / Hepatic Encephalopathy (HE) 1 4 Completed Treatment Constipation 2 4 Completed Treatment Hepatic Encephalopathy (HE) 1 4 Completed Treatment Hepatic Encephalopathy (HE) / Minimal Hepatic Encephalopathy 1 4 Recruiting Prevention Cirrhosis of the Liver / Hepatic Encephalopathy (HE) / Liver Diseases / Pathological Processes / Portal Hypertension 1 4 Recruiting Treatment Hepatic Encephalopathy (HE) 1
- Inalco spa
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- Actavis Group
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- Diversified Healthcare Services Inc.
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- Ivers Lee Division Of Jones Packaging Inc.
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- Merrell Pharmaceuticals Inc.
- Moeller Pharma GmbH and Co. KG
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- Pharmaceutical Association
- Pharmaceutical Packaging Center
- Physicians Total Care Inc.
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- United Research Laboratories Inc.
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- Dosage Forms
Form Route Strength Syrup Oral 3.335 g/5mL Powder Parenteral 10 g/10g Solution Oral 667 MG/ML Syrup Oral 667 mg / mL Syrup Oral 667 mg Syrup Oral; Rectal 10 g / 15 mL Solution Oral 66.7 g Syrup Oral Granule Powder Oral 95 g / 100 g Powder Oral 950 mg / g Solution Oral Liquid Oral; Rectal 10 g/15mL Granule, for solution Oral 3 g Granule, for solution Oral 9 g Syrup 65 % Granule, for solution Oral 12 G Granule, for solution Oral 6 G Powder, for solution Oral 12 g Powder, for solution Oral 3 g Powder, for solution Oral 6 g Powder, for solution Oral 9 g Solution Oral 200 ML Solution Oral 400 ML Syrup Oral 65 % Solution Oral 670 MG/ML Liquid Oral 667 mg / mL Solution Oral 667 mg / mL Powder, for solution Oral 10 g/10g Powder, for solution Oral 20 g/20g Solution Oral 650 mg/ml Syrup Oral 10 g / 15 mL Syrup Oral 66.7 g Solution Oral 10 g/15mL Solution Oral 10 g/10g Solution Oral 20 g/30mL Solution Oral; Rectal 10 g/15mL Syrup Oral 667 mg/ml Syrup Oral 66.7 G/100ML Solution Oral 10 g / 15 mL Syrup Oral 650 mg/ml Powder, for solution Oral Powder, for solution Oral 10 g Powder, for solution Oral 5 g Syrup Oral 180 ML Syrup Oral 370 ML Syrup Oral 66.6 % Syrup Oral 66.7 MG Syrup Oral 66.7 % Syrup Oral 90 ML Syrup 67 G/100ML Granule, for solution Rectal 200 G Syrup 66.7 % Syrup 66.7 G/100ML Granule, for solution Oral Granule, for solution Oral 10 G Syrup Powder Oral Syrup Oral 10 g/15ml Syrup Oral 120 ML Syrup Oral 200 ML Syrup Oral 250 ML Syrup Oral 400 ML Syrup 300 ML Syrup Oral 3.3 g / 5 mL
Unit description Cost Unit Kristalose 30 20 gm Packets Box 83.93USD box Kristalose 30 10 gm Packets Box 57.57USD box Enulose 10 gm/15ml Solution 473ml Bottle 37.83USD bottle Kristalose 20 gm packet 2.04USD each Kristalose 10 gm packet 1.67USD each Constulose 10 gm/15 ml soln 0.09USD ml Enulose 10 gm/15 ml solution 0.08USD ml Lactulose Encephalopathy 10 gm/15ml Solution 0.08USD ml Lactulose 10 gm/15ml Solution 0.07USD ml Generlac 10 gm/15 ml solution 0.05USD ml Apo-Lactulose 667 mg/ml Syrup 0.02USD ml Jamp-Lactulose 667 mg/ml Syrup 0.02USD ml Pms-Lactulose 667 mg/ml Syrup 0.02USD ml Ratio-Lactulose 667 mg/ml Syrup 0.02USD mlDrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
- Not Available
- Experimental Properties
Property Value Source melting point (°C) 169 °C http://www.hmdb.ca/metabolites/HMDB0000740 water solubility Soluble in cold water, hot water. Solubility in water: 76.4% @ 30 deg. C MSDS logP -4.3 http://www.hmdb.ca/metabolites/HMDB0000740
- Predicted Properties
Property Value Source Water Solubility 792.0 mg/mL ALOGPS logP -3.3 ALOGPS logP -4.5 ChemAxon logS 0.36 ALOGPS pKa (Strongest Acidic) 10.28 ChemAxon pKa (Strongest Basic) -3 ChemAxon Physiological Charge 0 ChemAxon Hydrogen Acceptor Count 11 ChemAxon Hydrogen Donor Count 8 ChemAxon Polar Surface Area 189.53 Å2 ChemAxon Rotatable Bond Count 5 ChemAxon Refractivity 68.77 m3·mol-1 ChemAxon Polarizability 31.49 Å3 ChemAxon Number of Rings 2 ChemAxon Bioavailability 0 ChemAxon Rule of Five No ChemAxon Ghose Filter No ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon
- Predicted ADMET Features
Property Value Probability Human Intestinal Absorption - 0.8407 Blood Brain Barrier + 0.6609 Caco-2 permeable - 0.8957 P-glycoprotein substrate Non-substrate 0.5805 P-glycoprotein inhibitor I Non-inhibitor 0.8575 P-glycoprotein inhibitor II Non-inhibitor 0.9425 Renal organic cation transporter Non-inhibitor 0.849 CYP450 2C9 substrate Non-substrate 0.8745 CYP450 2D6 substrate Non-substrate 0.854 CYP450 3A4 substrate Non-substrate 0.6605 CYP450 1A2 substrate Non-inhibitor 0.9472 CYP450 2C9 inhibitor Non-inhibitor 0.9556 CYP450 2D6 inhibitor Non-inhibitor 0.9386 CYP450 2C19 inhibitor Non-inhibitor 0.9134 CYP450 3A4 inhibitor Non-inhibitor 0.9774 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.9619 Ames test Non AMES toxic 0.9421 Carcinogenicity Non-carcinogens 0.9569 Biodegradation Not ready biodegradable 0.6719 Rat acute toxicity 1.2563 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.9692 hERG inhibition (predictor II) Non-inhibitor 0.8684
- Mass Spec (NIST)
- Not Available
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS Not Available GC-MS Spectrum - GC-EI-TOF GC-MS splash10-0uxr-0951000000-d976341b4e779d2fcb68 GC-MS Spectrum - GC-EI-TOF GC-MS splash10-0udj-0941000000-e16e35441da7b81d64a1 Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
- Escherichia coli (strain K12)
- Pharmacological action
- General Function
- Carbohydrate binding
- Specific Function
- The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme.
- Gene Name
- Uniprot ID
- Uniprot Name
- Evolved beta-galactosidase subunit alpha
- Molecular Weight
- 117878.225 Da
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Bjarnason I, Batt R, Catt S, Macpherson A, Maxton D, Menzies IS: Evaluation of differential disaccharide excretion in urine for non-invasive investigation of altered intestinal disaccharidase activity caused by alpha-glucosidase inhibition, primary hypolactasia, and coeliac disease. Gut. 1996 Sep;39(3):374-81. [Article]
- Cook GC: Breath hydrogen concentrations after oral lactose and lactulose in tropical malabsorption and adult hypolactasia. Trans R Soc Trop Med Hyg. 1978;72(3):277-81. [Article]
- Noone C, Menzies IS, Banatvala JE, Scopes JW: Intestinal permeability and lactose hydrolysis in human rotaviral gastroenteritis assessed simultaneously by non-invasive differential sugar permeation. Eur J Clin Invest. 1986 Jun;16(3):217-25. [Article]
- Hall BG, Malik HS: Determining the evolutionary potential of a gene. Mol Biol Evol. 1998 Aug;15(8):1055-61. [Article]
Drug created on June 13, 2005 13:24 / Updated on September 18, 2021 03:33