Sofpironium bromideProduct ingredient for Sofpironium
- Name
- Sofpironium bromide
- Drug Entry
- Sofpironium
Sofpironium is a "soft" anticholinergic analog of glycopyrronium that has been modified with a readily hydrolyzable ester moiety.6 Soft drugs are designed to reduce systemic toxicity while enhancing local efficacy by employing retrometabolic drug design, in which a molecule contains a metabolically sensitive moiety that promotes rapid metabolism to inactive metabolites after exerting activity at its target site.2 Sofpironium is rapidly converted to a less active metabolite, BBI-4010, after exerting its activity, thereby limiting the incidence and/or severity of systemic anticholinergic effects.5,6
Sofpironium bromide (Sofdra) was approved by the FDA in June 2024 for the topical treatment of primary axillary hyperhidrosis.4,5 It has also been available in Japan since 2020 under the brand name Ecclock.4
- Accession Number
- DBSALT003526
- Structure
Structure for Sofpironium bromide (DBSALT003526)
- Synonyms
- Sofpironium Br / Sofpironium bromide
- External IDs
- BBI 4000 / BBI-4000 / BBI4000
- UNII
- 7B2Y1932XU
- CAS Number
- 1628106-94-4
- Weight
- Average: 470.404
Monoisotopic: 469.146386 - Chemical Formula
- C22H32BrNO5
- InChI Key
- FIAFMTCUJCWADZ-JOFREBOKSA-M
- InChI
- InChI=1S/C22H32NO5.BrH/c1-3-27-20(24)16-23(2)14-13-19(15-23)28-21(25)22(26,18-11-7-8-12-18)17-9-5-4-6-10-17;/h4-6,9-10,18-19,26H,3,7-8,11-16H2,1-2H3;1H/q+1;/p-1/t19-,22+,23?;/m1./s1
- IUPAC Name
- SMILES
- [Br-].CCOC(=O)C[N+]1(C)CC[C@H](C1)OC(=O)[C@@](O)(C1CCCC1)C1=CC=CC=C1
- External Links
- ChEMBL
- CHEMBL3707223
- Wikipedia
- Sofpironium_bromide
- Predicted Properties
Property Value Source