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Sulfamethoxazole
go.drugbank.com/drugs/DB01015ApprovedInvestigationalSulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria. … [L11830] It is generally given in combination with [trimethoprim], which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps
Synonyms: 4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide, 3-Sulfanilamido-5-methylisoxazoleMixtures: SEPTRIN IV 5 ML 10 AMPUL, TRIMETOPRIMA 40 MG/5 ML SULFAMETOXAZOL 200MG/5 ML SUSPENSIONTiaprofenic acid
go.drugbank.com/drugs/DB01600ApprovedTiaprofenic acid is a non-steroidal anti-inflammatory drug employed in the treatment of pain, particularly arthritis pain. … It belongs to the _arylpropionic acid_ (profen) group of nonsteroidal anti-inflammatory drugs (NSAIDs).
Synonyms: 2-(5-Benzyl-2-thienyl)propionsäure, 2-(5-Benzoyl-thiophen-2-yl)-propionic acidCategories: Non COX-2 selective NSAIDSTrimethoprim
go.drugbank.com/drugs/DB00440ApprovedInvestigationalVet approved[L11893] Trimethoprim is often used in combination with [sulfamethoxazole] due to their complementary and synergistic mechanisms but may be used as a monotherapy in the treatment and/or prophylaxis of … Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it
Synonyms: 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine, 5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamineMixtures: SEPTRIN IV 5 ML 10 AMPUL, TRIMETOPRIMA 40 MG/5 ML SULFAMETOXAZOL 200MG/5 ML SUSPENSIONEdaravone
go.drugbank.com/drugs/DB12243ApprovedInvestigational[L44017] Edaravone was initially granted orphan designation by the European Medicines Agency on June 19, 2015 [L44007] and was under regulatory review in Europe. … Edaravone is a free radical scavenger and neuroprotective agent with antioxidant properties.[A254257] It has three tautomers.
Synonyms: 1-phenyl-3-methyl-5-oxo-2-pyrazoline, 3-methyl-1-phenyl-5-pyrazoloneCategories: Compounds used in a research, industrial, or household setting, Heterocyclic Compounds, 1-RingTribromsalan
go.drugbank.com/drugs/DB20138ApprovedWithdrawnTribromsalan is a small molecule drug. Tribromsalan has a monoisotopic molecular weight of 446.81 Da.
Synonyms: 3,4',5-tribromosalicylanilideMethylchloroisothiazolinone
go.drugbank.com/drugs/DB14197ApprovedIt is also a known dermatological sensitizer and allergen; some of its side effects include flaky or scaly skin, breakouts, redness or itchiness, and moderate to severe swelling in the eye area. … Methylchloroisothiazolinone (MCI) is an isothiazolinone commonly used as a preservative with antibacterial and antifungal properties.
Synonyms: 5-Chloro-N-methylisothiazolin-3-one, 4-Isothiazolin-3-one, 5-chloro-2-methyl-Categories: Compounds used in a research, industrial, or household setting, Heterocyclic Compounds, 1-RingEthotoin
go.drugbank.com/drugs/DB00754ApprovedEthotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. … Ethotoin is no longer commonly used.
Synonyms: (±)-3-ethyl-5-phenylhydantoin, 3-ethyl-5-phenylhydantoinCategories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersFactor IX Complex (Human)
go.drugbank.com/drugs/DB11330ApprovedInvestigationalFactor IX Complex is a sterile, lyophilized concentrate composed of a number of Vitamin K-dependent clotting factors found in functioning human plasma. … As the product Kcentra, Factor IX Complex is also indicated for the urgent reversal of acquired coagulation factor deficiency induced by Vitamin K antagonist (VKA, e.g., warfarin) therapy in adult patients
Synonyms: Coagulation factor IX, II, VII and X in combination, Factor IX ComplexMixtures: Bebulin Vh Inj 1000unit/vialTrifluridine
go.drugbank.com/drugs/DB00432ApprovedInvestigationalIt displays effective antiviral activity against Herpes simplex virus type 1 and 2 [A35271]. … It is an active antiviral agent in ophthalmic solutions used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus.
Synonyms: 5-Trifluoromethyl-2-deoxyuridine, 5-(Trifluoromethyl)deoxyuridineMixtures: LONSURF FILM-COATED TABLET 15 MG/6.14 MG, LONSURF FILM-COATED TABLET 15 MG/6.14 MGLeflunomide
go.drugbank.com/drugs/DB01097ApprovedInvestigationalLeflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. … Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous.
Synonyms: 4-ISOXAZOLECARBOXAMIDE, 5-METHYL-N-(4-(TRIFLUOROMETHYL)PHENYL)-, 5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamideCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Substrates