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Filgrastim
go.drugbank.com/drugs/DB00099ApprovedInvestigational[L36325] Filgrastim-sndz was approved on March 6, 2015 [L40768] and filgrastim-ayow was approved on March 2, 2022. … It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the sequence for expression in _E. Coli_.
Synonyms: r-metHuG-CSFInternational brands: White-COfloxacin
go.drugbank.com/drugs/DB01165ApprovedInvestigationalA synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Categories: Heterocyclic Compounds, 2-Ring, 4-QuinolonesSynonyms: 8-Fluoro-3-methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acidSimeprevir
go.drugbank.com/drugs/DB06290ApprovedWithdrawnThe SVR12 was 83% (29/35) in treatment-naïve patients and 86% (19/22) in relapsing patients. … In patients with HCV genotype 1 with compensated cirrhosis, the treatment is directed for 24 week duration.
Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitorsProducts: OLYSIO 150 MG KAPSUL ,KAPSUL, 28 ADETThalidomide
go.drugbank.com/drugs/DB01041ApprovedInvestigationalWithdrawnA piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. … Due to severe teratogenicity, pregnancy must be excluded before the start of treatment and patients must enrol in the THALIDOMID Risk Evaluation and Mitigation Strategy (REMS) program to ensure contraception
Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 SubstratesSynonyms: 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)isoindoline, α-N-phthalylglutaramideCrizotinib
go.drugbank.com/drugs/DB08865ApprovedInvestigational[L42460] By targeting the echinoderm microtubule-associated protein-like 4 (EML4)-ALK fusion protein, crizotinib offers robust effectiveness in treating NSCLC in patients with this type of rearrangement … [A250785] Crizotinib was the first-in-class drug used to treat ALK-positive tumors.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexSynonyms: (R)-crizotinibPegvisomant
go.drugbank.com/drugs/DB00082ApprovedInvestigationalPegvisomant is a highly selective growth hormone (GH) receptor antagonist. It is used to treat acromegaly. … Unlike dopamine or somatostatin analogs (which inhibit growth hormone secretion), this drug actually blocks the hepatic (GH-mediated) production of insulin like growth factor (IGF-1), which is the main
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersProducts: SOMAVERT® 15 MG POLVO LIOFILIZADO PARA SOLUCIÓN INYECTABLE, SOMAVERT 15 MG ENJEKSIYONLUK COZELTI ICIN TOZ ICEREN FLAKON VE COZUCU, 30 ADETCholic Acid
go.drugbank.com/drugs/DB02659ApprovedInvestigationalA major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. … [PubChem] Cholic acid, formulated as Cholbam capsules, is approved by the United States Food and Drug Administration as a treatment for children and adults with bile acid synthesis disorders due to single
Categories: P-glycoprotein inducersProducts: ORPHACOL ® 250 MG, ORPHACOL®50 MGOrnidazole
go.drugbank.com/drugs/DB13026InvestigationalOrnidazole has been used in trials studying the prevention of Elective Colorectal Surgery.
Mixtures: ORNISASIN 500 MG/500 MG FILM TABLET, 20 ADET, ORCIPOL 500 MG/500 MG FILM TABLET, 28 ADETCategories: Heterocyclic Compounds, 1-RingAcipimox
go.drugbank.com/drugs/DB09055ApprovedInvestigationalAcipimox inhibits the production of triglycerides by the liver and the secretion of VLDL, which leads indirectly to a modest reduction in LDL and increase in HDL. … Acipimox is a niacin derivative used as a hypolipidemic agent.
Categories: Heterocyclic Compounds, 1-RingProducts: OLBETAM CAPSULE 250 mgLevomenthol
go.drugbank.com/drugs/DB00825ApprovedInvestigationalMenthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils. … Forming clear or white waxy, crystalline substance, menthol is typically solid at room temperature. (-)-Menthol is the naturally-occurring and main form of menthol, and is assigned the (1R,2S,5R) configuration
Mixtures: OTACI TERMAL POMAD, 25 G, ยาแก้ปวดฟัน พาตาร์ 75 (ตราปืน เอ็ม 16)Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates