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Displaying results 991 - 1000 of 10000 in total
  1. Target

    G protein-coupled receptor 68

    go.drugbank.com/bio_entities/BE0014724
    TargetHumans

    The receptor is almost silent at pH 7.8 but fully activated at pH 6.8 (PubMed:12955148, PubMed:39753132). … Proton-sensing G protein-coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions (PubMed:12955148, PubMed:29677517, PubMed:32865988, PubMed

    Polypeptides: G protein-coupled receptor 68Synonyms: G protein-coupled receptor 12A, Ovarian cancer G protein-coupled receptor 1
  2. Target

    G protein-coupled receptor 84

    go.drugbank.com/bio_entities/BE0020007
    TargetHumans

    G protein-coupled receptor that responds endogenously to dietary fatty acids or nutrient, specifically medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. … In immune cells, functions as a pro-inflammatory receptor via 6-OAU and promotes the expression of pro-inflammatory mediators such as TNFalpha, IL-6 and IL-12B as well as stimulating chemotactic responses

    Polypeptides: G protein-coupled receptor 84Synonyms: Inflammation-related G protein-coupled receptor EX33
  3. Drug

    Gentamicin

    go.drugbank.com/drugs/DB00798
    ApprovedInvestigationalVet approved

    [A234349] It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability. … [A234364] This synergistic activity is not only important for the treatment of complex infections, but can also contribute to dose optimization and reduced adverse effects.

    Mixtures: FITODERM TC, GENTAMICINA E BETAMETASONE IDIProducts: Gentamicin(e), INYECCION DE SULFATO DE GENTAMICINA ISOTONICA 1.6 MG/ ML
  4. Drug

    Insulin human

    go.drugbank.com/drugs/DB00030
    ApprovedInvestigational

    to produce or synthesize the insulin needed to manage circulating blood sugar levels. … Insulin is released from the pancreas following a meal to promote the uptake of glucose from the blood into internal organs and tissues such as the liver, fat cells, and skeletal muscle.

    Mixtures: Novolin Ge 30/70, Novolin Ge 30/70Products: Novolin Ge Nph, Novolin Ge Toronto
  5. Drug

    Infigratinib

    go.drugbank.com/drugs/DB11886
    ApprovedInvestigationalWithdrawn

    [L34304] The FDA later announced the final withdrawal of the approval of infigratinib for this indication on May 16, 2024: This decision was based on the sponsor's request due to clinical trial recruitment … [A235174] Cholangiocarcinoma is the most common primary malignancy affecting the biliary tract and the second most common primary hepatic malignancy.

    Categories: Fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitors, Receptor, Fibroblast Growth Factor, Type 1, antagonists & inhibitors
  6. Drug

    Tryptophan

    go.drugbank.com/drugs/DB00150
    ApprovedInvestigationalNutraceuticalWithdrawn

    It can be a precursor to niacin, albeit inefficiently, in mammals.

    Mixtures: Clinimix E, Clinimix ECategories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
  7. Drug

    Casimersen

    go.drugbank.com/drugs/DB14984
    ApprovedInvestigational

    [A218186] Casimersen is the most recent in a line of approved PMOs for treating DMD, including [eteplirsen] and [viltolarsen]. … However, the specific mutations, and hence the precise exon skipping, targeted by each is different.

  8. Drug

    Polysilicone-15

    go.drugbank.com/drugs/DB11271
    Approved

    It is the first polymeric UVB filer consisting of chromophores attached to a silicone backbone [L2796, L2797, L2799, F87, F88, F89]. … The compound is a colorless to pale yellow viscous liquid which is soluble in organic solvents of medium polarity and insoluble in water [L2796, L2797, L2799, F87, F88, F89].

    Mixtures: BRING GREEN Tea Tree CICA Cooling Sun, The History Of Whoo Gongjinhyang Seol Whitening Sun
  9. Drug

    Codeine

    go.drugbank.com/drugs/DB00318
    ApprovedIllicitInvestigational

    The relief of pain (analgesia) is a primary goal for enhancing the quality of life of patients and for increasing the ability of patients to engage in day to day activities. … Codeine, an opioid analgesic, was originally approved in the US in 1950 and is a drug used to decrease pain by increasing the threshold for pain without impairing consciousness or altering other sensory

    Mixtures: Tl-hist CD, Tl-hist CmCategories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
  10. Drug

    Atropine

    go.drugbank.com/drugs/DB00572
    ApprovedInvestigationalVet approved

    [A251660,L42815,L42825,L42835] It has a variety of therapeutic applications, including pupil dilation and the treatment of anticholinergic poisoning and symptomatic bradycardia in the absence of reversible … [A251660] Atropine is a relatively inexpensive drug and is included in the World Health Organization List of Essential Medicines.[A251675]

    Mixtures: Re-PB Hyos, Re-PB HyosProducts: SULFATO DE ATROPINA 0.1 %, ATROPINE SULFAT IE AMPUL 1 MG/ML, 10 ADET