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Displaying results 1011 - 1020 of 10000 in total
  1. Target

    Gamma-hemolysin component B

    go.drugbank.com/bio_entities/BE0001964
    TargetStaphylococcus aureus (strain MW2)

    Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity. Promotes host AMFR-mediated inflammation by mediating 'Lys-27'-linked ubiquitination of TAB3, TAK1-TAB3 complex formation an...

    Synonyms: H-gamma-I
  2. Target

    Mannosyl-oligosaccharide glucosidase

    go.drugbank.com/bio_entities/BE0014425
    TargetHumans

    In the context of N-glycan degradation, cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner

    Synonyms: Processing A-glucosidase I
  3. Drug

    Beclomethasone dipropionate

    go.drugbank.com/drugs/DB00394
    ApprovedInvestigational

    [L6871] It is a prodrug of an active metabolite beclomethasone 17-monopropionate (17-BMP)[A179839] which acts on the glucocorticoid receptor to mediates its therapeutic action. … Beclomethasone dipropionate became first available in a pressurized metered-dose inhaler in 1972 and later in a dry powder inhaler and an aqueous nasal spray.

    Synonyms: (11β,16β)-9-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione, 9-chloro-11β-hydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-dipropionateInternational brands: Clenil-A
  4. Drug

    KITE-222

    go.drugbank.com/drugs/DB17195
    Investigational

    Synonyms: An autologous chimeric antigen receptor (CAR) T-cell therapy engineered to express an antibody-derived single-chain variable fragment that recognizes C-type lectin-like molecule-1 (CLL-1)
  5. Drug

    Ambroxol

    go.drugbank.com/drugs/DB06742
    ApprovedInvestigational

    Surfactants acts as an anti-glue factor by reducing the adhesion of mucus to the bronchial wall, in improving its transport and in providing protection against infection and irritating agents. … It stimulates synthesis and release of surfactant by type II pneumocytes.

    Mixtures: TUSIGEN NF, HISTIACIL NFCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  6. Target

    Arginase-1

    go.drugbank.com/bio_entities/BE0000286
    TargetEnzymeHumans

    Catalyzes the final step of the urea cycle by hydrolyzing L-arginine into urea, a nitrogenous waste product, and L-ornithine, a precursor to proline and polyamines; the urea cycle occurs primarily in the liver and, to a lesser extent, in...

    Synonyms: Type I arginase
  7. Target

    Neurexin-1

    go.drugbank.com/bio_entities/BE0005274
    TargetHumans

    They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. … Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions.

    Synonyms: Neurexin I-alpha
  8. Drug

    Estriol

    go.drugbank.com/drugs/DB04573
    ApprovedInvestigationalVet approved

    It is however available in the United States by prescription filled only by compounding pharmacies. … Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy, it is not approved for use by the FDA or Health Canada.

    Mixtures: HelloPharmacist Bi-EST 5.0 Cream, GYNOFLOR 50 MG/0.03 MG VAJİNAL TABLET, 6 ADETCategories: P-glycoprotein inducers, P-glycoprotein substrates
  9. Drug

    Remoxipride

    go.drugbank.com/drugs/DB00409
    ApprovedWithdrawn

    [A215422] It gained approval in the UK in 1989 but was withdrawn in 1993 after it was found to be associated with an increased incidence of aplastic anemia.[A215422,A215512] … Remoxipride is an atypical antipsychotic agent that is specific for dopamine D<sub>2</sub> receptors.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Inhibitors
  10. Drug

    Freneslerbart

    go.drugbank.com/drugs/DB19080
    Investigational

    Rhinitis Who Live With a Cat). … Freneslerbart is under investigation in clinical trial NCT04981717 (A Study to Examine the Efficacy and Safety of Anti-fel D 1 Antibodies Injections in Cat-allergic Adolescent and Adult Patients With Allergic

    Synonyms: Anti-cat allergen fel d 1 monoclonal anitbody regn-1908, Immunoglobulin G4 [227-proline], anti-(Felis catus allergen Fel d1) (human monoclonal REGN1908 γ4-chain), disulfide with human monoclonal REGN1908 κ-chain, dimer