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Displaying results 1031 - 1040 of 7604 in total
  1. Target

    Sequestosome-1

    go.drugbank.com/bio_entities/BE0014160
    TargetHumans

    Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed … following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for

    Synonyms: Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa
  2. Indication

    Salt-losing Androgenital syndrome

    go.drugbank.com/conditions/DBCOND0123106
    Drugs: Fludrocortisone
    Synonyms: Salt-losing Androgenital syndrome
  3. Drug

    Diamorphine

    go.drugbank.com/drugs/DB01452
    ApprovedIllicit

    As heroin, it is illegal to manufacture, possess, or sell in the United States and the UK. However, under the name diamorphine, heroin is a legal prescription drug in the United Kingdom. … Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed) Internationally, diamorphine is controlled under Schedules I and IV of the Single Convention on Narcotic Drugs.

    Categories: Heterocyclic Compounds with 4 or More Rings
  4. Drug

    Strontium chloride

    go.drugbank.com/drugs/DB13987
    ApprovedWithdrawn

    Such strontium chloride toothpaste formulations may subsequently not be available for sale anymore in certain parts of the world [A33167, A33168]. … Strontium chloride (SrCl2) is a salt of strontium and chloride.

  5. Drug

    Bunamiodyl

    go.drugbank.com/drugs/DB04814
    ApprovedWithdrawn

    Withdrawn from the Canadian, US, and UK markets in 1963 due to nephropathy.

  6. Drug

    Oxeladin

    go.drugbank.com/drugs/DB04822
    ApprovedWithdrawn

    Withdrawn from the Canadian, US, and UK markets in 1976 due to carcinogenicity.

  7. Drug

    Magnesium carbonate

    go.drugbank.com/drugs/DB09481
    Approved

    Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label].

    Mixtures: MAGONAT 365 MG GRANÜL IÇEREN SAŞE,30 SAŞE, Buffered Vitamin C Powder With Ca Mg and KCategories: Drugs for Constipation, Drugs for Acid Related Disorders
  8. Drug

    Deutivacaftor

    go.drugbank.com/drugs/DB15141
    ApprovedInvestigational

    [L52275,A179677] Deutivacaftor was first approved by the US FDA in December 2024 in combination with two CFTR correctors - [tezacaftor] and [vanzacaftor] - for the treatment of patients with responsive

  9. Drug

    Mitapivat

    go.drugbank.com/drugs/DB16236
    ApprovedInvestigational

    [A245478] On February 17, 2022, the FDA approved mitapivat as the first disease-modifying treatment for hemolytic anemia in adults with pyruvate kinase (PK) deficiency, a rare, inherited disorder leading … Defects in the pyruvate kinase enzyme in various red blood cells disorders lead to the lack of energy production for red blood cells, leading to lifelong premature destruction of red blood cells or chronic

  10. Drug

    Citric acid

    go.drugbank.com/drugs/DB04272
    ApprovedInvestigationalNutraceuticalVet approved

    [L14120] It is also used in combination with magnesium oxide to form magnesium citrate, an osmotic laxative.[L43832]

    Mixtures: Urologic G for Irrigation, Urologic G for IrrigationCategories: Disinfectants (For Agents Used on Object), Compounds used in a research, industrial, or household setting