Search

Displaying results 1041 - 1050 of 10000 in total
  1. Drug

    Secukinumab

    go.drugbank.com/drugs/DB09029
    ApprovedInvestigational

    [A249840] Following its first global approval in Japan in December 2014, secukinumab was approved by the European Commission on January 15, 2015, and by the FDA a few days after (January 21, 2015). … [A249805] It is currently approved to treat a number of chronic inflammatory conditions, such as plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, and hidradenitis suppurativa.

    Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsProducts: COSENTYX SOLUTION FOR INJECTION IN PREFILLED SYRINGE 75MG/0.5ML, Fraizeron 150mg Powder for Solution for Injection
  2. Drug

    Acetylcholine

    go.drugbank.com/drugs/DB03128
    ApprovedInvestigational

    It is generally not used as an administered drug because it is broken down very rapidly by cholinesterases, but it is useful in some ophthalmological applications. … Acetylcholine in vertebrates is the major transmitter at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in

    Synonyms: O-AcetylcholineCategories: Antiglaucoma Preparations and Miotics
  3. Drug

    Amisulpride

    go.drugbank.com/drugs/DB06288
    ApprovedInvestigational

    Amisulpride is a benzamide derivative and a dopamine receptor antagonist that selectively works on dopamine D2 and D3 receptors. … In the US, the intravenous formulation of amisulpride is used to treat and prevent postoperative nausea and vomiting in adults, either as monotherapy or in combination with another antiemetic agent of

    Categories: Benzamides and benzamide derivativesSynonyms: 4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-O-anisamide, 4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide
  4. Drug

    Ritonavir

    go.drugbank.com/drugs/DB00503
    ApprovedInvestigational

    It is now more commonly used as a booster of other protease inhibitors and is available in both liquid formulations and as capsules. … Although it was initially developed as an independent antiviral agent, it has been shown to possess advantageous properties in combination regimens with low-dose ritonavir and other protease inhibitors

    Mixtures: Kaletra Tablet 100mg/25mg, Kaletra 100mg/25mg Film-Coated TabletCategories: lopinavir and ritonavir, darunavir and ritonavir
  5. Drug

    Remdesivir

    go.drugbank.com/drugs/DB14761
    ApprovedInvestigational

    [L12174, L12177] After initially being granted an FDA Emergency Use Authorization (EUA) on May 1st, 2020,[L13236] remdesivir was fully approved by the FDA for the treatment of COVID-19 on October 22 … [A191379, A222393] Broad antiviral activity of remdesivir is suggested by its mechanism of action,[A222398] and to date, it has demonstrated _in vitro_ activity against the _Arenaviridae_, _Flaviviridae

    Categories: Amino Acids, Peptides, and Proteins, Nucleosides and NucleotidesProducts: COVIFOR (REMDESIVIR FOR INJECTION 100MG/VIAL), VEKLURY® LYOPHILIZED POWDER FOR IV INFUSION 100MG/VIAL
  6. Drug

    Methadone

    go.drugbank.com/drugs/DB00333
    ApprovedInvestigational

    Use of OAT is also intended to lead to social stabilization by reducing crime rates, incarceration, use of illicit opioids such as [heroin] or [fentanyl], and ultimately marginalization. … [A497,A5344] Specifically by inhibiting the NMDA receptor, methadone dampens a major excitatory pain pathway within the central nervous system.

    Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeProducts: Alphadone Syrup 10mg/ml, METADONA SOLUCIÓN ORAL 10MG/ML
  7. Drug

    Yohimbine

    go.drugbank.com/drugs/DB01392
    ApprovedInvestigationalVet approvedWithdrawn

    Yohimbine has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.

    Categories: Genito Urinary System and Sex Hormones, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeProducts: Yohimbine HCl 2mg, Yohimbine Tab 2mg
  8. Drug

    Nilutamide

    go.drugbank.com/drugs/DB00665
    ApprovedInvestigational

    Nilutamide is a pure, nonsteroidal anti-androgen with affinity for androgen receptors (but not for progestogen, estrogen, or glucocorticoid receptors). … Prostate cancer is mostly androgen-dependent and can be treated with surgical or chemical castration. To date, antiandrogen monotherapy has not consistently been shown to be equivalent to castration.

    Categories: Antineoplastic and Immunomodulating Agents, Hormone Antagonists and Related AgentsProducts: Anandron Tab 100mg, Anandron - Tab 100mg
  9. Target

    Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

    go.drugbank.com/bio_entities/BE0000423
    TargetTransporterHumans

    Transports non-alpha-amino acids such as beta-alanine with low affinity, and has a higher affinity for dipolar and cationic amino acids such as leucine and lysine (PubMed:18599538). … Can also transport carnitine, butirylcarnitine and propionylcarnitine coupled to the transmembrane gradients of Na(+) and Cl(-) (PubMed:17855766)

    Polypeptides: Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
  10. Drug

    Racephedrine

    go.drugbank.com/drugs/DB14752
    Approved

    Categories: Herbs and Natural Products, Alpha-and Beta-adrenergic AgonistsProducts: Fyto-HB Tea - 10mg/pck, Zand Decongestant Herbal Cap