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Olfactory Transduction OR5A1
smpdb.ca/view/SMP0713868PhysiologicalThis ion flow depolarizes the membrane and, if threshold is reached, triggers an action potential. … Notably, OR2A4 is part of the OR2A subfamily, which includes receptors with overlapping ligand specificity and broad responsiveness to terpenoid and aromatic alcohols.
Enzymes: Calcium-activated chloride channel regulator 1Olfactory Transduction OR1E3
smpdb.ca/view/SMP0713869PhysiologicalThe OR1E3 receptor has been shown to respond to floral and fruity odorants, particularly citronellol and related alcohols with rose-like or citrus notes. … When odorant molecules enter the nasal cavity and dissolve in the mucus layer, certain ligands selectively bind to the OR1E3 receptor.
Enzymes: Calcium-activated chloride channel regulator 1Olfactory Transduction OR1C1
smpdb.ca/view/SMP0713870PhysiologicalOnce the depolarization reaches threshold, an action potential is generated and transmitted along the olfactory nerve to the olfactory bulb. … When odorant molecules enter the nasal cavity and dissolve in the mucus layer, specific ligands bind to the OR1C1 receptor.
Enzymes: Calcium-activated chloride channel regulator 1Olfactory Transduction OR1L3
smpdb.ca/view/SMP0713871PhysiologicalThe OR1L3 receptor has been shown to respond to several floral and aromatic compounds, including helional, cinnamaldehyde, and citronellol. … Variations in OR1L3 gene expression or sequence among individuals may influence sensitivity and perception of these types of odors.
Enzymes: Calcium-activated chloride channel regulator 1Olfactory Transduction OR2W1
smpdb.ca/view/SMP0713865PhysiologicalCalcium influx further opens chloride (Cl⁻) channels, amplifying the depolarization. … brain regions for odor perception and identification.
Enzymes: Calcium-activated chloride channel regulator 1Rabeprazole Action Pathway
smpdb.ca/view/SMP0000229Drug actionA chloride ion is transported into the gastric endothelial cell through a chloride anion exchanger and is transported out of the cell through a chloride intracellular channel protein 2, back into the gastric … It is used as an anti-ulcer medication, and helps relieve gastric acid reflux, gastric irritation and gastric pain.
Enzymes: Chloride intracellular channel protein 2Pirenzepine Action Pathway
smpdb.ca/view/SMP0000246Drug actionTherefore, pirenzipine can be used for treating peptic ulcers, prevent motion sickness, vomiting and nausea. … Binding of pirenzepine on the receptor will decrease the level of exertion of gastric acid secretion, and also it can reduce muscle spasms.
Enzymes: Chloride intracellular channel protein 2Roxatidine Acetate Action Pathway
smpdb.ca/view/SMP0000734Drug actionA chloride ion is transported into the gastric endothelial cell through a chloride anion exchanger and is transported out of the cell through a chloride intracellular channel protein 2, back into the gastric … The potassium transporting ATPase also converts water and ATP to a phosphate molecule and ADP. Alongside the transporters, potassium is brought into the cell.
Enzymes: Chloride intracellular channel protein 2Betazole Action Pathway
smpdb.ca/view/SMP0000736Drug actionGastric acid digests protein and absorbs calcium, iron and vitamin B12. Gastric acidity may also interfere with medication bioavailability. … Betazole, also known as ametazole and Histalog, is a histamine H2 agonist that causes an increase in gastric acid secretion. Betazole is commonly used to evaluate acid production.
Enzymes: Chloride intracellular channel protein 2Esomeprazole Action Pathway (Old)
smpdb.ca/view/SMP0000225Drug actionIn this pathway, esomeprazole is taken orally and is oxidized in the stomach to form the active metabolite of esomeprazole. … Because the drug binds covalently, its effects are dose-dependent and last much longer than similar drugs that bind to the protein non-covalently.
Enzymes: Chloride intracellular channel protein 2