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Umeclidinium
go.drugbank.com/drugs/DB09076ApprovedInvestigational80%. … [A7715] Maintenance of the airway is controlled by the parasympathetic nervous system, particularly by the abundance of the muscarinic subtype 3 (M3) in the airway smooth muscle.
Mixtures: TRELEGY ELLİPTA 100 MCG + 62,5 MCG +25 MCG KULLANIMA HAZIR İNHALASYON TOZU, 30 DOZ, TRELEGY ELLIPTA INHALATION POWDER 100 MCG/62.5 MCG/25 MCGSynonyms: 1-[2-(benzyloxy)ethyl]-4-[hydroxy(diphenyl)methyl]-1-azoniabicyclo[2.2.2]octaneTiotropium
go.drugbank.com/drugs/DB01409ApprovedInvestigational[A180163] Tiotropium was granted FDA approval on 30 January 2004.[L7084] … [A180163,L7084,L7087,L7090,L7093] Tiotropium acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation and bronchodilation.
Mixtures: ROPITAL 18/2 MCG INHALASYON IÇIN TOZ IÇEREN KAPSÜL , 120 KAPSÜL, ROPITAL 18/2 MCG INHALASYON IÇIN TOZ IÇEREN BLISTER , 60 DOZCategories: Heterocyclic Compounds, 2-RingCalcitriol
go.drugbank.com/drugs/DB00136ApprovedInvestigationalNutraceuticalCalcitriol is an active metabolite of vitamin D with 3 hydroxyl (OH) groups and is commonly referred to as 1,25-dihydroxycholecalciferol, or 1alpha,25-dihydroxyvitamin D<sub>3</sub>, 1,25-dihydroxyvitamin … [DB00146] undergoes hydroxylation to form calcitriol via 1α-hydroxylase (CYP27B1) activity [A26353]. Calcitriol is considered to be the most potent metabolite of vitamin D in humans [A3366].
Synonyms: 1α,25(OH)2D3, 1α,25-dihydroxyvitamin D3Products: CALCITRIOLO EG, CALCIJEX 1 MCG/ML IV AMPUL, 25 ADETDupilumab
go.drugbank.com/drugs/DB12159ApprovedInvestigational[L7186,L7192,L41439] Dupilumab is currently under investigations for potential therapeutic use in diseases driven by allergic reactions or type 2 inflammation, such as pediatric atopic dermatitis, and … It was first approved by the FDA in 2017.
Products: DUPİXENT 200 mg/ 1,14ml ENJEKSİYONLUK ÇÖZELTİ İÇEREN KULLANIMA HAZIR ENJEKTÖR, 1 ADET, DUPIXENT SOLUTION FOR INJECTION IN A PRE-FILLED SYRINGE 200 mg/1.14mlTestosterone enanthate
go.drugbank.com/drugs/DB13944ApprovedInvestigational[A31615] This testosterone derivative was first approved on December 24, 1953.[L8941] In 2017, about 6.5 million retail prescriptions for testosterone therapy were filled [L4659]. … As recent as 1 October 2018, the US FDA approved Antares Pharma Inc.'
Products: TESTOVIRON® DEPOT POR 250 MG, TESTOSTERONA ENANTATO INYECCION 250 MGFibrinogen human
go.drugbank.com/drugs/DB09222ApprovedInvestigationalIt works by replacing a specific protein in the blood, fibrinogen (factor I), that helps with blood clotting. … It is indicated for the treatment of acute bleeding episodes in patients with both acquired and congenital fibrinogen deficiency, including afibrinogenemia and hypofibrinogenemia.[L41065]
Mixtures: EVICEL Fibrin Sealant (Human) Solution, 50-90 mg/ml, 800-1200 IU/ml, ARTISS 10 ML ÇÖZELTİ İÇEREN KULLANIMA HAZIR ENJEKTOR, 1 ADETProducts: VERASEAL SOLUTIONS FOR SEALANT, 80 mg/ml, 500 IU/ml, Haemocomplettan P 1g/2g Pulver zur Herstellung einer Injektions-/InfusionslösungLorlatinib
go.drugbank.com/drugs/DB12130ApprovedInvestigationalinclude lorlatinib as a first-line treatment option in advanced ALK-positive NSCLC. … It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-positive non-small cell lung cancer, followed by an expanded approval in 2022 to
Categories: MATE 1 Inhibitors, Heterocyclic Compounds, 1-RingProducts: LORBRENA® 25 MG, LORBRENA® 100 MGChlorthalidone
go.drugbank.com/drugs/DB00310ApprovedInvestigational[A173863] In particular, the ALLHAT trial confirmed the role of thiazide diuretics as first-line therapy and demonstrated that chlorthalidone had a statistically significant lower incidence of stroke and … [A176324] Chlorthalidone is considered first-line therapy for management of uncomplicated hypertension as there is strong evidence from meta-analyses that thiazide diuretics such as chlorthalidone reduce
Mixtures: TENORETIC 100 MG/25 MG FILM TABLET, 28 ADET, BRASARTAN® CTDN 160/25 MGCategories: Heterocyclic Compounds, 2-RingEvolocumab
go.drugbank.com/drugs/DB09303ApprovedInvestigationalIt is approved for both homozygous and heterozygous familial cholesterolemia as an adjunct to other first-line therapies. … Evolocumab is designed to bind to PCSK9 and inhibit PCSK9 from binding to LDL receptors on the liver surface, resulting in more LDL receptors on the surface of the liver to remove LDL-C from the blood.
Products: REPATHA 140 MG/ML SC ENJEKSIYONLUK COZELTI ICEREN KULLANIMA HAZIR KALEM, 2 ADET, REPATHA® 140 MG/MLEconazole
go.drugbank.com/drugs/DB01127ApprovedIt is used topically in dermatomycoses also orally and parenterally.
Mixtures: TRILON-E CREAM, Econazole Nitrate 1% / Niacinamide 4%Categories: 14-alpha Demethylase Inhibitors, Heterocyclic Compounds, 1-Ring