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4-(4-fluoro-phenylazo)-5-imino-5H-pyrazol-3-ylamine
go.drugbank.com/drugs/DB08667ExperimentalThis compound belongs to the fluorobenzenes. These are compounds containing one or more fluorine atoms attached to a benzene ring. This substance targets the protein methionine aminopeptidase.
Cemiplimab
go.drugbank.com/drugs/DB14707ApprovedInvestigationalBy blocking PD-1, cemiplimab works to enhance T cell-mediated antitumour responses. … [A39201,A254177,L4615] It was later approved to be used in basal cell carcinoma and non-small non-small cell lung cancer.
Loncastuximab tesirine
go.drugbank.com/drugs/DB16222ApprovedInvestigationalRelapsed and refractory B-cell acute lymphoblastic leukemia (B-ALL) are a therapeutic challenge for patients who have undergone prior systemic therapies with limited success. … [A234439] Prognosis is poor and more effective therapies are needed to treat relapsed/refractory cases and improve survival.
Synonyms: Humanized monoclonal immunoglobulin G1 antibody directed against human CD19 conjugated to SG3199 through A protease cleavable valine-alanine linkerDexibuprofen
go.drugbank.com/drugs/DB09213ApprovedWithdrawnIt is proposed to be more pharmacologically active and tolerable with a better safety profile than ibuprofen due to higher concentration of active S enantiomer. … For Metabolism, Enzymes, Carriers, Transporters Sections, refer to [Ibuprofen].
Fluvastatin
go.drugbank.com/drugs/DB01095ApprovedInvestigationalFluvastatin belongs to a class of medications called statins and is used to reduce plasma cholesterol levels and prevent cardiovascular disease. … HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis.
Products: FLUVASTATINA DOC GENERICI, FLUVASTATINA MYLAN GENERICSBetaine
go.drugbank.com/drugs/DB06756ApprovedInvestigationalNutraceuticalCurrently, no treatments are available to correct the genetic causes of homocystinuria. … [L43105] Although it is present in many food products, the levels found there are insufficient to treat this condition.
Mixtures: Mega Lipotropic Fmla W B6bet, Glutamic Acid HCl Betaine HCl W PepsinSynthetic Conjugated Estrogens, B
go.drugbank.com/drugs/DB09318ApprovedThere is currently no generic form of CEEs available as a detailed analytical characterization of the active ingredients or of their estrogenic activity is not available at this time. … Prior to menopause, the primary source of estrogen is the ovarian follicle, which secretes 70-500 micrograms of estradiol daily, depending on the phase of the menstrual cycle.
Anagrelide
go.drugbank.com/drugs/DB00261ApprovedInvestigationalAnagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. … [A214274] It appears to carry a better response rate than other thrombocythemia treatments (e.g. [busulfan], [hydroxyurea]) and may be better tolerated.[A214274]
Technetium Tc-99m disofenin
go.drugbank.com/drugs/DB09164ApprovedWithdrawnTechnetium Tc-99m is a metastable nuclear isomer and disofenin is an iminodiacetic acid derivative with no known pharmacologic actions at the doses recommended. … It is well suited for both planar and single photon tomographic scintigraphy to quantitatively measure the function of liver, gallbladder and bile ducts and detect any anatomical changes in the hepatobliary
Peginterferon alfa-2a
go.drugbank.com/drugs/DB00008ApprovedInvestigationalPeginterferon alfa-2a is derived from the alfa-2a moeity of recombinant human interferon and acts by binding to human type 1 interferon receptors. … Peginterferon alfa-2a was used alongside [DB00811] with the intent to cure, or achieve a sustained virologic response (SVR), after 48 weeks of therapy.