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Zilucoplan
go.drugbank.com/drugs/DB15636ApprovedInvestigational[L48701] It was also later approved by the EMA on December 4, 2023, as an add-on treatment for the same condition.[L49131] In July 2024, it was approved by Health Canada for the same indication.
Carbidopa
go.drugbank.com/drugs/DB00190ApprovedInvestigational[T394] The first approved product by the FDA containing only carbidopa was developed by Amerigens Pharmaceuticals Ltd and approved on 2014. … An individual formulation containing solely carbidopa was generated to treat nausea in patients where the combination therapy [levodopa]/carbidopa is not efficient reducing nausea.
Mixtures: PMS-levodopa-carbidopa, PMS-levodopa-carbidopaAcetrizoic acid
go.drugbank.com/drugs/DB09347ApprovedWithdrawn[A32135] It was first synthesized by Wallingford in 1953[A32136] and it was filled in the FDA by the Johnson & Johnson subsidiary, Cilag Chemie AG, on February 8th, 1978. … Acetrizoic acid presents the molecular formula of 3-acetamidol-2,4,6-triiodobenzoic acid[L1702] and it is the first monomeric ionic compound used as an X-ray contrast agent.
Aloe vera leaf
go.drugbank.com/drugs/DB13906ApprovedInvestigationalWhile aloe vera has a long history of commercial uses, it is still widely used in cosmetic, food and pharmaceutical products. … The use of aloe vera in constipation, inflammatory disorders, cancer, ulcer, and diabetes has also been investigated [A32476].
Thallous chloride
go.drugbank.com/drugs/DB09316ApprovedWithdrawnIt is used as a diagnostic radiopharmaceutical. It is used for diagnosis of heart and parathyroid problems. … Thallous chloride (also known as Thallium(I) chloride) is a colourless solid intermediate in the isolation of thallium from its ores.
Prednisone
go.drugbank.com/drugs/DB00635ApprovedInvestigationalVet approved[L10502] Prednisone was granted FDA approval on 21 February 1955.[L10496]
Megestrol acetate
go.drugbank.com/drugs/DB00351ApprovedInvestigationalVet approvedA progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. … It has also been used in the palliative treatment of breast cancer.
Tofisopam
go.drugbank.com/drugs/DB08811InvestigationalAlthough Tofisopam is not approved for sale in North America, it is approved for use in various countries worldwide, including parts of Europe.
Bismuth subsalicylate
go.drugbank.com/drugs/DB01294ApprovedVet approved[A230733] Bismuth subsalicylate has been around for over 100 years: it was originally developed in 1901 for hygienic use and sanitation for cholera infection. … [A230728, A230773] Bismuth subsalicylate was first approved by the FDA in 1939 and is now mainly used to relieve nausea, diarrhea, and gastrointestinal discomfort.
Fencamfamin
go.drugbank.com/drugs/DB01463ApprovedIllicitWithdrawnFencamfamin (Glucoenergan, Reactivan) is a stimulant which was developed in the 1960s as an appetite suppressant.