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Elraglusib
go.drugbank.com/drugs/DB16047InvestigationalElraglusib is under investigation in clinical trial NCT04218071 (Actuate 1901: 9-ING-41 in Myelofibrosis).
Synonyms: 1H-Pyrrole-2,5-dione, 3-(5-fluoro-3-benzofuranyl)-4-(5-methyl-5H-1,3-dioxolo(4,5-F)indol-7-yl)-, 3-(5-Fluoro-benzofuran-3-yl)-4-(5-methyl-5H-(1,3)dioxolo(4,5-F)indol-7-yl)-pyrrole-2,5-dioneVepdegestrant
go.drugbank.com/drugs/DB19006ApprovedInvestigational[A275508] Specifically, vepdegestrant is being developed as a first-line or subsequent treatment option for patients whose tumors grow in response to estrogen and have progressed after standard therapies … Vepdegestrant is a potent, selective, and orally bioavailable PROteolysis TArgeting Chimera (PROTAC) small molecule estrogen receptor (ER) degrader.
Synonyms: 2,6-piperidinedione, 3-(1,3-dihydro-1-oxo-5-(4-((1-(4-((1r,2s)-1,2,3,4-tetrahydro-6-hydroxy-2-phenyl-1-naphthalenyl)phenyl)-4-piperidinyl)methyl)-1-piperazinyl)-2h-isoindol-2-yl)-, (3s)-Categories: P-glycoprotein inhibitors, Cytochrome P-450 CYP2B6 InhibitorsAdenylate-3'-phosphate-[[2'-deoxy-uridine-5'-phosphate]-3'-phosphate]
go.drugbank.com/drugs/DB03186ExperimentalSynonyms: Adenylate-3'-phosphate-[[2'-deoxy-uridine-5'-phosphate]-3'-phosphate], U-PI-A-PIHonokiol
go.drugbank.com/drugs/DB19283InvestigationalHonokiol is under investigation in clinical trial NCT00966953 (Development of Clinical Method to Determination Triclosan Retention in Plaque Following Brushing.).
Categories: Heterocyclic Compounds, 2-RingSynonyms: 3',5-diallyl-2,4'-biphenyldiol, (1,1'-biphenyl)-2,4'-diol, 3',5-di-2-propen-1-yl-Phosphoaminophosphonic acid guanylate ester
go.drugbank.com/drugs/DB02082ExperimentalA non-hydrolyzable analog of GTP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It binds tightly to G-protein in the presence of Mg2+. … The nucleotide is a potent stimulator of adenylate cyclase.
Categories: Heterocyclic Compounds, 2-RingSynonyms: 5'-guanylylimidodiphosphate, Guanosine 5'-[beta,gamma-imido]triphosphateBrivudine monophosphate
go.drugbank.com/drugs/DB04438ExperimentalSynonyms: Bvdu 5'-monophosphate, BVDU-MPFurvina
go.drugbank.com/drugs/DB16547ExperimentalFurvina is marketed in Cuba as Dermofural®, an ointment containing G1 as the only active principle ingredient. It is used to treat dermatological infections.[A228063] … Furvina (G1) is an antimicrobial agent active against Gram-positive and Gram-negative bacteria, yeasts, and filamentous fungi.
Synonyms: 1-(5-Bromofur-2-yl)-2-bromo-2-nitroethene, 2-Bromo-5-(2-bromo-2-nitrovinyl)furanCategories: Heterocyclic Compounds, 1-RingRiboflavin tetrabutyrate
go.drugbank.com/drugs/DB14727InvestigationalSynonyms: Riboflavin 2',3',4',5'-tetrabutyrate, Riboflavin, 2',3',4',5'-tetrabutanoateCategories: Heterocyclic Compounds, 2-Ring, Heterocyclic Compounds, 3-RingAPL-030
go.drugbank.com/drugs/DB18735ExperimentalAPL-030 is a orally-active small molecule inhibitor of GCN2.
Synonyms: N-(4-((2-aminopyrimidin-5-yl)ethynyl)-3-fluoropyridin-2-yl)-5-chloro-2-methoxypyridine-3-sulfonamideNimodipine
go.drugbank.com/drugs/DB00393ApprovedInvestigationalNimodipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. … Compared to other calcium channel blocking agents, nimodipine exhibits greater effects on cerebral circulation than on peripheral circulation.
Synonyms: isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate, 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-methoxyethyl ester 5-isopropyl esterCategories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates