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Vepdegestrant

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

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Data Packages
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Identification

Generic Name
Vepdegestrant
DrugBank Accession Number
DB19006
Background

Vepdegestrant is under investigation in clinical trial NCT05909397 (A Study of ARV-471 (PF-07850327) Plus Palbociclib Versus Letrozole Plus Palbociclib in Participants With Estrogen Receptor Positive, Human Epidermal Growth Factor Negative Advanced Breast Cancer).

Type
Small Molecule
Groups
Investigational
Structure
Similar Structures
Weight
Average: 723.918
Monoisotopic: 723.378455078
Chemical Formula
C45H49N5O4
Synonyms
  • 2,6-piperidinedione, 3-(1,3-dihydro-1-oxo-5-(4-((1-(4-((1r,2s)-1,2,3,4-tetrahydro-6-hydroxy-2-phenyl-1-naphthalenyl)phenyl)-4-piperidinyl)methyl)-1-piperazinyl)-2h-isoindol-2-yl)-, (3s)-
External IDs
  • ARV-471
  • Arv-471 (protac)
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
WC1U3R1YMI
CAS number
2229711-68-4
InChI Key
TZZDVPMABRWKIZ-XMOGEVODSA-N
InChI
InChI=1S/C45H49N5O4/c51-37-12-15-39-33(27-37)8-13-38(31-4-2-1-3-5-31)43(39)32-6-9-35(10-7-32)48-20-18-30(19-21-48)28-47-22-24-49(25-23-47)36-11-14-40-34(26-36)29-50(45(40)54)41-16-17-42(52)46-44(41)53/h1-7,9-12,14-15,26-27,30,38,41,43,51H,8,13,16-25,28-29H2,(H,46,52,53)/t38-,41+,43+/m1/s1
IUPAC Name
SMILES
OC1=CC=C2[C@H]([C@H](CCC2=C1)C1=CC=CC=C1)C1=CC=C(C=C1)N1CCC(CN2CCN(CC2)C2=CC=C3C(=O)N(CC3=C2)[C@H]2CCC(=O)NC2=O)CC1

References

General References
Not Available
ChemSpider
114935295
ChEMBL
CHEMBL5095210
Wikipedia
Vepdegestrant

Clinical Trials

Clinical Trials
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PhaseStatusPurposeConditionsCountStart DateWhy Stopped100+ additional columns
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3Active Not RecruitingTreatmentBreast Cancer1somestatusstop reasonjust information to hide
3RecruitingTreatmentAdvanced Breast Cancer1somestatusstop reasonjust information to hide
2Active Not RecruitingTreatmentBreast Cancer1somestatusstop reasonjust information to hide
2RecruitingTreatmentAngiosarcoma / Breast Cancer / Breast Neoplasms / Breast Tumor / HER2/Neu-positive Breast Cancer / Hormone Receptor Negative Tumor / Hormone Receptor Positive Tumor / Human Epidermal Growth Factor 2 Negative Carcinoma of Breast / Locally Advanced Breast Cancer (LABC) / Stage I Breast Cancer / Triple-Negative Breast Cancer1somestatusstop reasonjust information to hide
1, 2Active Not RecruitingTreatmentBreast Cancer1somestatusstop reasonjust information to hide

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at June 28, 2024 17:35 / Updated at June 29, 2024 07:29