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Bedaquiline
go.drugbank.com/drugs/DB08903ApprovedInvestigational[A261866] Although it is closely related to fluoroquinolones, bedaquiline does not affect DNA gyrase; instead, bedaquiline inhibits the c subunit of ATP synthase responsible for synthesizing ATP. … Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline.
Vanzacaftor
go.drugbank.com/drugs/DB18373ApprovedInvestigationalIt is used alongside other CFTR correctors and CFTR potentiators to increase the quantity and function of CFTR at the cell surface in patients with cystic fibrosis. … ], a CFTR potentiator, for the treatment of patients with responsive CFTR mutations.
Iron sucrose
go.drugbank.com/drugs/DB09146ApprovedInvestigationalIron sucrose (sucroferric oxyhydroxide or iron saccharate) is used as a source of iron in patients with iron deficiency anemia with chronic kidney disease (CKD), including those who are undergoing dialysis
Products: HIERRO SACARATO EQUIVALENTE A HIERRO ELEMENTAL 100 MG/ 5ML.Lutein
go.drugbank.com/drugs/DB00137ApprovedNutraceuticalIn green plants, xanthophylls act to modulate light energy and serve as non-photochemical quenching agents to deal with triplet chlorophyll (an excited form of chlorophyll), which is overproduced at very … Lutein is an xanthophyll and one of 600 known naturally occurring carotenoids.
Gamolenic acid
go.drugbank.com/drugs/DB13854ApprovedWithdrawnEvening primrose oil has been investigated for clinical use in menopausal syndrome, diabetic neuropathy, and breast pain, where gamolenic acid is present at concentrations of 7-14% [F27]. … Gamolenic acid is produced minimally in the body as the delta 6-desaturase metabolite of [DB00132]. It is converted to [DB00154], a biosynthetic precursor of monoenoic prostaglandins such as PGE1.
Thiotepa
go.drugbank.com/drugs/DB04572ApprovedInvestigationalIt is a stable derivative of N,N',N''- triethylenephosphoramide (TEPA). It is mostly used to treat breast cancer, ovarian cancer and bladder cancer. … It is also used as conditioning for Bone marrow transplantation. Its main toxicity is myelosuppression.
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexDopamine
go.drugbank.com/drugs/DB00988ApprovedInvestigationalA family of receptors (receptors, dopamine) mediate its action. … It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement.
Mixtures: INYECCION DE CLORHIDRATO DE DOPAMINA 800 MCG/ML DEXTROSA AL 5% UPS, INYECCION DE CLORHIDRATO DE DOPAMINA EN DEXTROSA AL 5% USP (1600 MCG/ML)Categories: Monoamine Oxidase A Substrates, Compounds used in a research, industrial, or household settingHuman botulinum neurotoxin A/B immune globulin
go.drugbank.com/drugs/DB14115ApprovedInfant botulism is a rare infectious disease occurring in infants in which _Clostridium botulinum_ colonize the large intestine and being to produce botulinum neurotoxin directly in the gut. … to more serious symptoms such as respiratory arrest and flaccid paralysis.
Synonyms: Human botulinum neurotoxin A/B immune globulinChlorobutanol
go.drugbank.com/drugs/DB11386ApprovedVet approvedWithdrawnAs a long-term stabilizer of multi-ingredient preparations, chlorobutanol is normally used at a concentration of 0.5%. At this concentration, it also conserves its antimicrobial activity. … Due to the long terminal half-life of 37 days, the use of chlorobutanol as a sedative is limited because of the considerable accumulation which will occur following multiple dosing [A32743].
Categories: Compounds used in a research, industrial, or household settingAvatrombopag
go.drugbank.com/drugs/DB11995ApprovedInvestigational[A33095] Thrombocytopenia is a common complication in patients suffering from chronic liver disease, occurring as a result of liver disease or a consequence of interferon-based antiviral therapy. … [L2931] It is administered orally as the salt form avatrombopag maleate.