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Clomifene
go.drugbank.com/drugs/DB00882ApprovedInvestigationalA triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue.
Categories: Sex Hormones and Modulators of the Genital SystemTioguanine
go.drugbank.com/drugs/DB00352ApprovedInvestigationalAn antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
Pegloticase
go.drugbank.com/drugs/DB09208ApprovedInvestigationalPegloticase is a porcine recombinant PEGylated uricase indicated for the treatment of chronic gout in adult patients that do not respond to other types of therapies. … [L42425] Pegloticase has a longer terminal elimination half-life thanks to the addition of a polyethylene glycol (PEG) group.
Categories: Compounds used in a research, industrial, or household settingSufentanil
go.drugbank.com/drugs/DB00708ApprovedInvestigationalAlso known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to warrant the use of an opioid analgesic in certified medically supervised healthcare settings … This route of administration is intended to be a simple, effective, non-invasive analgesic option to enable healthcare professionals to rapidly manage acute pain without difficult intravenous or epidural
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeThiethylperazine
go.drugbank.com/drugs/DB00372ApprovedInvestigationalWithdrawnThis piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) … A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins.
Categories: Dopamine D2 Receptor AntagonistsInositol nicotinate
go.drugbank.com/drugs/DB08949ApprovedWithdrawnIt is used in food supplements as a source of niacin (vitamin B3), where hydrolysis of 1 g (1.23 mmol) inositol hexanicotinate yields 0.91 g nicotinic acid and 0.22 g inositol. … Inositol nicotinate, also known as Inositol hexaniacinate/hexanicotinate or "no-flush niacin", is a niacin ester and vasodilator.
Dosulepin
go.drugbank.com/drugs/DB09167ApprovedInvestigationalIt is not FDA-approved due to low therpeutic index and significant toxicity in overdose. … Dosulepsin is a thio derivative of [DB00321] with a similar efficacy to that of [DB00321], and also exhibits anticholinergic, antihistamine and central sedative properties [L882].
Categories: Combined Inhibitors of Serotonin/Norepinephrine Reuptake, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeTyrosine
go.drugbank.com/drugs/DB00135ApprovedInvestigationalNutraceuticalTyrosine is a non-essential amino acid. In animals it is synthesized from [phenylalanine]. It is also the precursor of [epinephrine], thyroid hormones, and melanin.
Mixtures: AA-Ven, Appformin-DMethadone
go.drugbank.com/drugs/DB00333ApprovedInvestigational(due to a lack of active metabolites), minimal accumulation in renal failure, good bioavailability, low cost, and a long duration of action. … [A185888,A185891,A185897] Compared with [morphine], the gold standard reference opioid, methadone also acts as an agonist of κ- and σ-opioid receptors, as an antagonist of the N-methyl-D-aspartate (NMDA
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeSynonyms: dl-MethadonePemigatinib
go.drugbank.com/drugs/DB15102ApprovedInvestigational[A193719] FGFRs gained attention as potential therapeutic targets in selected cancers, as FGFR gene alterations were observed in a wide variety of cancers including those of the urinary bladder, breast … growth factor receptor 2 (FGFR2) gene fusion or other rearrangements as detected by an FDA-approved test.