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Displaying results 1141 - 1150 of 3732 in total
  1. Target

    G protein-coupled bile acid receptor 1

    go.drugbank.com/bio_entities/BE0005788
    TargetHumans

    G protein-coupled receptor for bile acid (PubMed:12419312, PubMed:12524422, PubMed:32698187, PubMed:32747649, PubMed:35858343).

    Polypeptides: G protein-coupled bile acid receptor 1Synonyms: G protein-coupled receptor GPCR19, Membrane-type receptor for bile acids
  2. Target

    Lymphatic vessel endothelial hyaluronic acid receptor 1

    go.drugbank.com/bio_entities/BE0010044
    TargetHumans

    Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding ...

    Polypeptides: Lymphatic vessel endothelial hyaluronic acid receptor 1Synonyms: Hyaluronic acid receptor
  3. Target

    Nuclear receptor subfamily 4immunitygroup A member 1

    go.drugbank.com/bio_entities/BE0010494
    TargetHumans

    Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' (PubMed:18690216, PubMed:8121493, PubMed:9315652).

    Polypeptides: Nuclear receptor subfamily 4immunitygroup A member 1Synonyms: Testicular receptor 3, Orphan nuclear receptor HMR
  4. Target

    Tumor necrosis factor receptor superfamily member 18

    go.drugbank.com/bio_entities/BE0010519
    TargetHumans

    Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death.

    Polypeptides: Tumor necrosis factor receptor superfamily member 18Synonyms: Activation-inducible TNFR family receptor
  5. Target

    Low-density lipoprotein receptor-related protein 6

    go.drugbank.com/bio_entities/BE0012061
    TargetHumans

    Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes (PubMed:11357136, PubMed:11448771

    Polypeptides: Low-density lipoprotein receptor-related protein 6
  6. Target

    Tyrosine-protein phosphatase non-receptor type 2

    go.drugbank.com/bio_entities/BE0012706
    TargetHumans

    Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. … May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Also plays an important role in glucose homeostasis.

    Polypeptides: Tyrosine-protein phosphatase non-receptor type 2
  7. Target

    Tumor necrosis factor receptor superfamily member EDAR

    go.drugbank.com/bio_entities/BE0021253
    TargetHumans

    Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death

    Polypeptides: Tumor necrosis factor receptor superfamily member EDARSynonyms: EDA-A1 receptor, Ectodysplasin-A receptor
  8. Target

    T cell receptor beta variable 6-5

    go.drugbank.com/bio_entities/BE0021562
    TargetHumans

    V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447).

    Polypeptides: T cell receptor beta variable 6-5
  9. Drug

    CHF 4227

    go.drugbank.com/drugs/DB05882
    Experimental

    Additionally, the compound has shown no uterotrophic activity suggesting a potential therapeutic advantage over drugs normally used in postmenopausal therapy. … CHF 4227 is a new selective estrogen receptor modulator (SERM).

  10. Drug

    CM4620

    go.drugbank.com/drugs/DB16466
    Investigational

    CM4620 (Zegocractin), is under investigation in multiple clinical trials, including NCT04195347 (pancreatitis due to asparaginase), NCT03709342 (PK/PD study in acute pancreatitis), NCT03401190 and NCT04681066