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Nirogacestat
go.drugbank.com/drugs/DB12005ApprovedInvestigationalbe 41% compared to 8% with the placebo. … [A262561] Nirogacestat was approved under the brand name OGSIVEO on November 27, 2023, by the FDA for the treatment of adult patients with progressing desmoid tumors who require systemic treatment.
RTA 744
go.drugbank.com/drugs/DB05920InvestigationalAnthracyclines are one of the most broadly used and effective classes of cancer therapies; however, they are not used to treat brain cancers because current therapies do not cross the blood-brain barrier
Erdafitinib
go.drugbank.com/drugs/DB12147ApprovedInvestigationalpersonalized treatment targeting susceptible FGFR genetic alterations for patients with metastatic bladder cancer, which demonstrates the development of more personalized and precise medicines tailoring to … Considering urothelial cancer is statistically the fourth most common kind of cancer in the world, the introduction of erdafitinib offers a much-needed new option in the ever-expanding therapeutic tool kit to
Pheniprazine
go.drugbank.com/drugs/DB09250ApprovedWithdrawnPheniprazine was withdrawn by its manufacturer due to its ability to cause toxicity in the liver and its ability to cause optic neuritis.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeCapmatinib
go.drugbank.com/drugs/DB11791ApprovedInvestigational[A199122] Aberrant c-Met activation - via mutations, amplification, and/or overexpression - is known to occur in many types of cancer, and leads to overactivation of multiple downstream signaling pathways … [A199122] This co-occurrence has made c-Met a desirable target in the treatment of NSCLC.
Amylmetacresol
go.drugbank.com/drugs/DB13908ApprovedThe acute sore throat (pharyngitis) is one of the most common conditions for which children are seen in the primary care setting.
Carfentanil
go.drugbank.com/drugs/DB01535IllicitInvestigationalVet approvedCarfentanil or carfentanyl (Wildnil) is an analogue of the popular synthetic opioid analgesic fentanyl, and is one of the most potent opioids known (also the most potent opioid used commercially). … Currently sufentanil, approximately 10–20 times less potent (500 to 1000 times the efficacy of morphine per weight) than carfentanil, is the maximum strength fentanyl analog for use in humans.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeLasmiditan
go.drugbank.com/drugs/DB11732ApprovedInvestigational[A187316,A187322] Lasmiditan, in contrast, is a highly selective agonist of 5-HT<sub>1F</sub> receptors, carrying virtually no affinity for other receptors which appear to be largely responsible for … [sumatriptan]) have seen preferential use in the acute treatment of migraines due to their relatively favourable efficacy and safety.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome(1R)-1-(2-thienylacetylamino)-1-phenylmethylboronic acid
go.drugbank.com/drugs/DB08552ExperimentalThis compound belongs to the benzenes and substituted derivatives. These are aromatic compounds containing at least one benzene ring. This medication targets the protein beta-lactamase.
Aminohippuric acid
go.drugbank.com/drugs/DB00345ApprovedInvestigationalWithdrawnIts sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity. [PubChem]