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Robenidine
go.drugbank.com/drugs/DB11542ExperimentalVet approvedRobenidine is used to control coccidiosis, a lethal infection in poultry which has shown a significant economic burden. … Robenidine is identified as a coccidiostat drug, which slows both the growth and reproductive cycles of coccidian parasites.
Detomidine
go.drugbank.com/drugs/DB11556InvestigationalVet approvedDetomidine is an α2-adrenergic agonist that is used as a horse sedative. Normally, it is administered in the salt form, detomidine hydrochloride.
Categories: Heterocyclic Compounds, 1-Ring, Adrenergic alpha-2 Receptor AgonistsSynonyms: 4-(2,3-dimethylbenzyl)imidazoleAminacrine
go.drugbank.com/drugs/DB11561InvestigationalA highly fluorescent anti-infective dye used clinically as a topical antiseptic and experimentally as a mutagen, due to its interaction with DNA. It is also used as an intracellular pH indicator.
Categories: Heterocyclic Compounds, 3-Ring, Compounds used in a research, industrial, or household settingSynonyms: 9-acridinamine, 5-aminoacridineFerric oxide
go.drugbank.com/drugs/DB11576ApprovedInvestigationalIron(III) oxide or ferric oxide is the inorganic compound with the formula Fe2O3. It is one of the three main oxides of iron, the other two being iron(II) oxide (FeO) the rarer form, and iron(II,III) oxide (Fe3O4) which naturally as magn...
Mixtures: L-Topical CALAMINE 8% ZINC OXIDE 8%, CALAMINA 8% LOCIONCategories: Compounds used in a research, industrial, or household settingLevoleucovorin
go.drugbank.com/drugs/DB11596ApprovedInvestigationalCommercially available leucovorin is composed of a 1:1 racemic mixture of the dextrorotary and levorotary isomers, while levoleucovorin contains only the pharmacologically active levo-isomer. … This results in a deficiency of coenzymes and a resultant buildup of toxic substances that are responsible for numerous adverse side effects of methotrexate therapy.
Categories: Vitamin B Complex, Heterocyclic Compounds, 2-RingSynonyms: N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid, L-LeucovorinDehydrocholic acid
go.drugbank.com/drugs/DB11622ApprovedDehydrocholic acid is a synthetic bile acid that was prepared from the oxidation of cholic acid with chromic acid [A33022]. It has been used for stimulation of biliary lipid secretion.
Mixtures: PLASIL®ENZIMATICOAmifampridine
go.drugbank.com/drugs/DB11640ApprovedPatients with LEMS develop serum antibodies against presynaptic P/Q-type voltage-gated calcium channels, leading to decreased presynaptic calcium levels and reduced quantal release of acetylcholine, which … In phase III clinical trials of adult patients with LEMS, treatment of amifampridine significantly improved symptoms of LEMS compared to placebo with good tolerance [A33864].
Categories: Heterocyclic Compounds, 1-RingSelumetinib
go.drugbank.com/drugs/DB11689ApprovedInvestigational[A193533,A193608] While some patients with this disorder develop PNs, this is considered relatively uncommon compared to other variants of NF-1. … NF-1 is considered rare, with an estimated incidence of 1/3000 individuals.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesNaldemedine
go.drugbank.com/drugs/DB11691ApprovedInvestigationalIt is a modified form of [DB00704] to which a side chain has been added to increase molecular weight and polar surface area resulting in restricted transport across the blood brain barrier.
Categories: Heterocyclic Compounds with 4 or More RingsTropisetron
go.drugbank.com/drugs/DB11699ApprovedInvestigationalWithdrawnAs a selective serotonin receptor antagonist, tropisetron competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingProducts: NAVOBAN 5 MG 1 AMPUL, Navoban 5 mg - Kapseln