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Vismodegib
go.drugbank.com/drugs/DB08828ApprovedInvestigational[A258613,A258618,L45803] It was discovered by high-throughput screening of a library of small-molecule compounds and subsequent optimization through medicinal chemistry. … Afterwards, it is silenced in all cells and tissues, except for hair, skin and stem cells.
Sotrovimab
go.drugbank.com/drugs/DB16355ApprovedInvestigational[L34425, L34430, L34440] However, in April 2022, the FDA removed the EUA for sotrovimab due to the rising COVID-19 cases caused by the Omicron BA.2 sub-variant, where the drug is ineffective. … found to reduce the risk of death or hospitalization in high-risk adults with COVID-19 in the outpatient setting.
Categories: Antiinfectives for Systemic Use, Approved Treatments for COVID-19Products: Sotrovimab for InjectionChlorquinaldol
go.drugbank.com/drugs/DB13306ApprovedChlorquinaldol is currently approved by the European Medicines Agency as a combination tablet with promestriene for the treatment of bacterial vaginosis.[F4552] … Chlorquinaldol was used historically as a topical antiseptic under the trade name Sterosan.
Icatibant
go.drugbank.com/drugs/DB06196ApprovedInvestigational[A4017,A263046] Icatibant was approved by the FDA on August 25, 2011, and by the EMA in 2008 as a treatment for hereditary angioedema. … relief was observed to be 8 hours compared to 36 hours for the placebo treatment.
Diethylstilbestrol
go.drugbank.com/drugs/DB00255ApprovedWithdrawn(Merck, 11th ed) The FDA withdrew its approval for the use of all oral and parenteral drug products containing 25 milligrams or more of diethylstilbestrol per unit dose.[L43942] … A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals.
Categories: Hormonal Contraceptives for Systemic UseZanubrutinib
go.drugbank.com/drugs/DB15035ApprovedInvestigationaltrial whose tumour is entirely or partially destroyed by a drug. … [L10163] Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long-term survival.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2B6 Substrates with a Narrow Therapeutic IndexOxybutynin
go.drugbank.com/drugs/DB01062ApprovedInvestigationalDue to its urinary symptoms that include nocturia, urgency, and frequency, this condition causes social embarrassment and a poor quality of life. … Overactive bladder (OAB) is a common condition negatively impacting the lives of millions of patients worldwide.
Categories: Drugs for Urinary Frequency and IncontinenceProducts: OXYBUTYNIN AL 5, Oxytrol For WomenChlordiazepoxide
go.drugbank.com/drugs/DB00475ApprovedIllicitAn anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal.
Mixtures: Pro Chlorax, AA PHARMA CHLORAX CAPSULEFomivirsen
go.drugbank.com/drugs/DB06759ApprovedWithdrawnThe drug was withdrawn by the FDA because while there was a high unmet need for drugs to treat CMV when the drug was initially discovered and developed due to the CMV arising in people with AIDS, the development … Fomivirsen is a antisense 21 mer phosphorothioate oligonucleotide.
Categories: Compounds used in a research, industrial, or household settingBelinostat
go.drugbank.com/drugs/DB05015ApprovedInvestigationalIt was US-approved in July 2014 as a therapeutic agent for relapsed or refractory peripheral T-cell lymphoma. … Belinostat is a novel agent that inhibits the enzyme histone deacetylase (HDAC) with a sulfonamide-hydroxamide structure.
Categories: UGT1A1 Substrates with a Narrow Therapeutic Index, P-glycoprotein substrates with a Narrow Therapeutic Index