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Displaying results 111 - 120 of 134502 in total
  1. Pathway

    Lactose Intolerance

    smpdb.ca/view/SMP0000458
    Disease

    Lactase deficiency is most prevalent in Asia, Africa and Indigenous populations in North and South America. … The symptoms of lactose intolerance include diarrhea, bloating, abdominal pain and excessive flatus.

    Drugs: ATP · Potassium cation · Lactose
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  2. Pathway

    Trehalose Degradation

    smpdb.ca/view/SMP0000467
    Metabolic

    It is produced by some plants, bacteria, fungi and invertebrates, and can be used as a source of energy, such as for flight in insects, and as a survival mechanism to avoid freezing and dehydration. … From there, the glucose enters the blood stream, and is transported to liver hepatocytes.

    Drugs: ATP · Potassium cation
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  3. Pathway

    Omeprazole Action Pathway

    smpdb.ca/view/SMP0122674
    Drug action

    In parietal cells, carbonic anhydrase converts water and carbon dioxide to hydrogen bicarbonate ions and H+. … The H+/K+ ATPase is located on the apical membrane and pumps the H+ from the cell into the stomach lumen and K+ from the lumen into the cell.

    Drugs: Omeprazole · Potassium cation · Zinc
    Enzymes: Potassium-transporting ATPase alpha chain 1, Potassium-transporting ATPase subunit beta
  4. Pathway

    Esomeprazole Action Pathway

    smpdb.ca/view/SMP0123196
    Drug action

    In parietal cells, carbonic anhydrase converts water and carbon dioxide to hydrogen bicarbonate ions and H+. … The H+/K+ ATPase is located on the apical membrane and pumps the H+ from the cell into the stomach lumen and K+ from the lumen into the cell.

    Drugs: Esomeprazole · Potassium cation · Zinc
    Enzymes: Potassium-transporting ATPase alpha chain 1, Potassium-transporting ATPase subunit beta
  5. Pathway

    Lansoprazole Action Pathway

    smpdb.ca/view/SMP0123261
    Drug action

    In parietal cells, carbonic anhydrase converts water and carbon dioxide to hydrogen bicarbonate ions and H+. … The H+/K+ ATPase is located on the apical membrane and pumps the H+ from the cell into the stomach lumen and K+ from the lumen into the cell.

    Drugs: Lansoprazole · Potassium cation · Zinc
    Enzymes: Potassium-transporting ATPase alpha chain 1, Potassium-transporting ATPase subunit beta
  6. Pathway

    Ethacrynic Acid Diuretic Action Pathway

    smpdb.ca/view/SMP0124515
    Drug action

    This is relieves symptoms such as swelling/ edema and hypertension in patients. Ethacrynic acid may also inhibit sodium and chloride reabsorption in the proximal and distal tubules. … Ethacrynic acid binds to NKCC2 transporter and inhibits it, preventing Na+, K+ and Cl- reabsorption from the lumen.

    Drugs: Etacrynic acid · Potassium cation
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  7. Pathway

    Lactose Intolerance

    smpdb.ca/view/SMP0125808
    Disease

    Lactase deficiency is most prevalent in Asia, Africa and Indigenous populations in North and South America. … The symptoms of lactose intolerance include diarrhea, bloating, abdominal pain and excessive flatus.

    Drugs: ATP · Potassium cation · Lactose
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  8. Pathway

    Furosemide Diuretic Action Pathway

    smpdb.ca/view/SMP0122712
    Drug action

    It binds to this transporter, inhibiting it and preventing Na+, K+ and Cl- reabsorption from the lumen. … This is relieves symptoms such as swelling/ edema and hypertension in patients. Furosemide may also inhibit sodium and chloride reabsorption in the proximal and distal tubules.

    Drugs: Furosemide · Potassium cation
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  9. Pathway

    Omeprazole Metabolism Pathway (old)

    smpdb.ca/view/SMP0000613
    Drug metabolism

    This active metabolite then binds covalently to the potassium-transporting ATPase protein subunits, found at the secretory surface of the gastric parietal cell, preventing any stimulus. … Losec and Zegerid, is a proton pump inhibitor (PPI) class drug that suppresses the final step in gastric acid production, and was the first proton pump inhibitor to e developed.

    Drugs: Omeprazole
    Enzymes: Potassium-transporting ATPase alpha chain 1, Potassium-transporting ATPase subunit beta
  10. Pathway

    Kidney Function - Ascending Limb of The Loop of Henle

    smpdb.ca/view/SMP0121010
    Physiological

    Chloride, potassium, and sodium are co-transported across the apical membrane (closest to the lumen) via transporters from the filtrate. … In addition, the three ions are transported across the basolateral membrane (closest to the renal interstitium) via other means such as the sodium potassium ATPase transports and the chloride channels

    Drugs: Potassium cation · Urea
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1