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Mechanisms of Fibrosis
smpdb.ca/view/SMP0540197SignalingECM to the actin cytoskeleton, enabling fibroblasts to migrate and exert force during tissue remodeling. … Myofibroblasts are characterized by their contractile properties and their ability to secrete large amounts of ECM, including collagen, driving tissue stiffness and fibrosis.
Drugs: Magnesium cationEnzymes: Mast/stem cell growth factor receptorPeginterferon alfa-2a Action Pathway
smpdb.ca/view/SMP0125981Drug actionThey act through IKKa and IKKb to drive NFKB induction of genes associated with survival signals, antigen processing and presentation, and proliferation. … This is used to stimulate the innate antiviral response in the treatment of hepatitis B and C viruses.
Drugs: Peginterferon alfa-2aEnzymes: Signal transducer and activator of transcription 3, Signal transducer and activator of transcription 2Peginterferon alfa-2b Action Pathway
smpdb.ca/view/SMP0126026Drug actionIts immunomodulatory effects are the enhancement of the phagocytic activity, the activation of NK cells, the stimulation of cytotoxic T-lymphocytes, and the upregulation of the Th1 T-helper cell subset … The mechanism of action is the inhibition of the viral replication in infected cells caused by the binding of the peginterferon to the human type 1 interferon receptors causing them to dimerize.
Drugs: Peginterferon alfa-2bEnzymes: Signal transducer and activator of transcription 3, Signal transducer and activator of transcription 2Interferon beta-1a Action Pathway
smpdb.ca/view/SMP0126027Drug actionThey act through IKKa and IKKb to drive NFKB induction of genes associated with survival signals, antigen processing and presentation, and proliferation. … When phosphorylated, the receptors bind to Stat1 and Stat2, and together with the interferon regulatory factor (IRF9) they form the interferon-stimulated gene factor 3 (ISGF3).
Drugs: Interferon beta-1aEnzymes: Signal transducer and activator of transcription 3, Signal transducer and activator of transcription 2Triflusal Action Pathway (new)
smpdb.ca/view/SMP0126547Drug actionDue to the anticoagulant and antiplatelet nature, herbs and supplements with similar activity should be avoided such as garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba. … Triflusal is administered orally and acts as an antithrombotic anticoagulant that irreversibly inhibits cyclooxygenase-1(COX-1) also known as prostaglandin g/h synthase 1.
Drugs: Adenosine phosphate · ATP · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Mesoheme +2 moreEnzymes: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10ACardiolipin Biosynthesis CL(10:0/10:0/14:0/21:0)
smpdb.ca/view/SMP0175412MetabolicSixth, phosphatidylglycerophosphatase and protein-tyrosine phosphatase dephosphorylates PGP to form phosphatidylglycerol (PG). … Second, the mitochondrial outer membrane enzyme glycerol-3-phosphate acyltransferase esterifies an acyl-group to the sn-1 position of sn-glycerol 3-phosphate to form 1-acyl-sn-glycerol 3-phosphate (lysophosphatidic
Drugs: NADH · Cytidine-5'-Triphosphate · sn-glycerol 3-phosphate · Pyrophosphoric acid · Dihydroxyacetone phosphateEnzymes: Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1Cardiolipin Biosynthesis CL(10:0/10:0/17:0/19:0)
smpdb.ca/view/SMP0175481MetabolicSixth, phosphatidylglycerophosphatase and protein-tyrosine phosphatase dephosphorylates PGP to form phosphatidylglycerol (PG). … Second, the mitochondrial outer membrane enzyme glycerol-3-phosphate acyltransferase esterifies an acyl-group to the sn-1 position of sn-glycerol 3-phosphate to form 1-acyl-sn-glycerol 3-phosphate (lysophosphatidic
Drugs: NADH · Cytidine-5'-Triphosphate · sn-glycerol 3-phosphate · Pyrophosphoric acid · Dihydroxyacetone phosphateEnzymes: Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1Cardiolipin Biosynthesis CL(10:0/10:0/17:0/21:0)
smpdb.ca/view/SMP0175483MetabolicSixth, phosphatidylglycerophosphatase and protein-tyrosine phosphatase dephosphorylates PGP to form phosphatidylglycerol (PG). … Second, the mitochondrial outer membrane enzyme glycerol-3-phosphate acyltransferase esterifies an acyl-group to the sn-1 position of sn-glycerol 3-phosphate to form 1-acyl-sn-glycerol 3-phosphate (lysophosphatidic
Drugs: NADH · Cytidine-5'-Triphosphate · sn-glycerol 3-phosphate · Pyrophosphoric acid · Dihydroxyacetone phosphateEnzymes: Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1Cardiolipin Biosynthesis CL(10:0/10:0/17:0/i-22:0)
smpdb.ca/view/SMP0175496MetabolicSixth, phosphatidylglycerophosphatase and protein-tyrosine phosphatase dephosphorylates PGP to form phosphatidylglycerol (PG). … Second, the mitochondrial outer membrane enzyme glycerol-3-phosphate acyltransferase esterifies an acyl-group to the sn-1 position of sn-glycerol 3-phosphate to form 1-acyl-sn-glycerol 3-phosphate (lysophosphatidic
Drugs: NADH · Cytidine-5'-Triphosphate · sn-glycerol 3-phosphate · Pyrophosphoric acid · Dihydroxyacetone phosphateEnzymes: Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1Cardiolipin Biosynthesis CL(10:0/10:0/17:0/i-24:0)
smpdb.ca/view/SMP0175497MetabolicSixth, phosphatidylglycerophosphatase and protein-tyrosine phosphatase dephosphorylates PGP to form phosphatidylglycerol (PG). … Second, the mitochondrial outer membrane enzyme glycerol-3-phosphate acyltransferase esterifies an acyl-group to the sn-1 position of sn-glycerol 3-phosphate to form 1-acyl-sn-glycerol 3-phosphate (lysophosphatidic
Drugs: NADH · Cytidine-5'-Triphosphate · sn-glycerol 3-phosphate · Pyrophosphoric acid · Dihydroxyacetone phosphateEnzymes: Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1