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Nitroprusside
go.drugbank.com/drugs/DB00325ApprovedInvestigationalNitroprusside serves as a source of nitric oxide, a potent peripheral vasodilator that affects both arterioles and venules (venules more than arterioles). … Nitroprusside is often administered intravenously to patients who are experiencing a hypertensive emergency.
Categories: Compounds used in a research, industrial, or household settingProducts: N-PRUS, PRUSIAT®Calcium glucoheptonate
go.drugbank.com/drugs/DB00326ApprovedInvestigationalCalcium supplements such as calcium gluceptate are taken by individuals who are unable to get enough calcium in their regular diet or who have a need for more calcium.
Synonyms: Calcium glucoheptonate (1:2), calcium bis[(2ξ)-D-glycero-D-gulo-heptonate]Indomethacin
go.drugbank.com/drugs/DB00328ApprovedInvestigational-3-acetic acid. … NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlorobenzoyl)25-methoxy-2-methylindole
Mixtures: INDOBIOTIC GOZ DAMLASI, 5 MLCategories: P-glycoprotein inhibitors, P-glycoprotein substratesEthambutol
go.drugbank.com/drugs/DB00330ApprovedInvestigational[A229048] It was developed out of a need for therapies active against isoniazid resistant strains of _Mycobacterium tuberculosis_.[A229048] Ethambutol was granted FDA approval on 6 November 1967. … Ethambutol is a bacteriostatic agent indicated alongside medications such as [isoniazid], [rifampin], and [pyrazinamide] in the treatment of pulmonary tuberculosis.
Mixtures: PRO TB 4, ริมสตาร์ 4 - FDCCategories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP2A6 InhibitorsMetformin
go.drugbank.com/drugs/DB00331ApprovedInvestigationalIt is commonly described as an "insulin sensitizer", leading to a decrease in insulin resistance and a clinically significant reduction of plasma fasting insulin levels. … Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.
Mixtures: AMARYL®M 1 MG/ 500 MG, AMARYL®M 4 MG/ 1000 MGCategories: MATE 1 Substrates, MATE 2 SubstratesMethadone
go.drugbank.com/drugs/DB00333ApprovedInvestigationalMethadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. … [A185888,A185891,A185897] Compared with [morphine], the gold standard reference opioid, methadone also acts as an agonist of κ- and σ-opioid receptors, as an antagonist of the N-methyl-D-aspartate (NMDA
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesSynonyms: 6-Dimethylamino-4,4-diphenyl-3-heptanoneOmeprazole
go.drugbank.com/drugs/DB00338ApprovedInvestigationalVet approvedOriginally approved by the FDA in 1989, omeprazole is a _proton-pump inhibitor_, used to treat gastric acid-related disorders.
Mixtures: ORAZOLE ® 10 MG CAPSULACategories: P-glycoprotein inhibitors, P-glycoprotein substratesPyrazinamide
go.drugbank.com/drugs/DB00339ApprovedInvestigationalA pyrazine that is used therapeutically as an antitubercular agent.
Mixtures: RINCURE ® 3 FDC TABLETAS CON PELICULA, PRO TB 4Categories: Heterocyclic Compounds, 1-RingProtriptyline
go.drugbank.com/drugs/DB00344ApprovedTCAs also block histamine H<sub>1</sub> receptors, alpha<sub>1</sub>-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred … See toxicity section below for a complete listing of side effects. Protriptyline may be used for the treatment of depression.
Categories: P-glycoprotein inhibitorsSynonyms: 3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-1-amine, 3-(5H-dibenzo[a,d]cyclohepten-5-yl)-N-methyl-1-propanamineTrimethadione
go.drugbank.com/drugs/DB00347ApprovedWithdrawnAn anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-Ring