Calcium glucoheptonate

Identification

Summary

Calcium glucoheptonate is a calcium supplement combined with calcium gluconate to treat hypocalcemia and maintain calcium levels.

Generic Name

DrugBank Accession Number

DB00326

Background

Calcium supplements such as calcium gluceptate are taken by individuals who are unable to get enough calcium in their regular diet or who have a need for more calcium. They are used to prevent or treat several conditions that may cause hypocalcemia (not enough calcium in the blood). The body needs calcium to make strong bones. Calcium is also needed for the heart, muscles, and nervous system to work properly.

Type

Small Molecule

Groups

Approved

Structure

Similar Structures

Weight: Average: 490.425
Monoisotopic: 490.084675939
Chemical Formula: C₁₄H₂₆CaO₁₆

Synonyms

Calcii glucoheptonas
calcium (2ξ)-D-gluco-heptonate
calcium bis[(2ξ)-D-glycero-D-gulo-heptonate]
calcium bis[(2ξ)-D-glycero-D-ido-heptonate]
calcium bis[(3R,4S,5R,6R)-2,3,4,5,6,7-hexahydroxyheptanoate]
Calcium gluceptate
Calcium glucoheptonat
Calcium glucoheptonate
Calcium glucoheptonate (1:2)
Glucoheptonate de calcium
Glucoheptonato calcico

Pharmacology

Indication: For treatment of mild hypocalcemia due to neonatal tetany, tetany due to parathyroid deficiency or vitamin D deficiency, and alkalosis, as prophylaxis of hypocalcemia during exchange transfusions, in the treatment of intestinal malabsorption, and to replenish electrolytes.

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Pharmacodynamics: Calcium supplements such as calcium gluceptate are taken by individuals who are unable to get enough calcium in their regular diet or who have a need for more calcium. They are used to prevent or treat several conditions that may cause hypocalcemia (not enough calcium in the blood). The body needs calcium to make strong bones. Calcium is also needed for the heart, muscles, and nervous system to work properly. The bones serve as a storage site for the body's calcium. They are continuously giving up calcium to the bloodstream and then replacing it as the body's need for calcium changes from day to day. When there is not enough calcium in the blood to be used by the heart and other organs, your body will take the needed calcium from the bones. When you eat foods rich in calcium, the calcium will be restored to the bones and the balance between your blood and bones will be maintained.
Mechanism of action: Calcium gluceptate replenishes the deminished levels of calcium in the body, returning them to normal levels.
Absorption: Rapidly absorbed following oral administration.
Volume of distribution: Not Available
Protein binding: Not Available
Metabolism: Not Available
Route of elimination: Not Available
Half-life: Not Available
Clearance: Not Available
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Toxicity: Symptoms of overdose include confusion, drowsiness (severe), high blood pressure, increased sensitivity of eyes or skin to light, irregular, fast, or slow heartbeat, and unusually large amount of urine or increased frequency of urination.
Pathways: Not Available
Pharmacogenomic Effects/ADRs: Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

Drug	Interaction
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Acebutolol	The therapeutic efficacy of Acebutolol can be decreased when used in combination with Calcium glucoheptonate.
Acetyldigitoxin	Calcium glucoheptonate may increase the arrhythmogenic and cardiotoxic activities of Acetyldigitoxin.
Alendronic acid	The serum concentration of Alendronic acid can be decreased when it is combined with Calcium glucoheptonate.
Alfacalcidol	The risk or severity of adverse effects can be increased when Alfacalcidol is combined with Calcium glucoheptonate.
Amiodarone	The therapeutic efficacy of Amiodarone can be decreased when used in combination with Calcium glucoheptonate.
Amlodipine	The therapeutic efficacy of Amlodipine can be decreased when used in combination with Calcium glucoheptonate.
Atenolol	The therapeutic efficacy of Atenolol can be decreased when used in combination with Calcium glucoheptonate.
Bendroflumethiazide	Bendroflumethiazide may decrease the excretion rate of Calcium glucoheptonate which could result in a higher serum level.
Benzthiazide	Benzthiazide may decrease the excretion rate of Calcium glucoheptonate which could result in a higher serum level.
Bepridil	The therapeutic efficacy of Bepridil can be decreased when used in combination with Calcium glucoheptonate.

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Food Interactions

No interactions found.

Products

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Brand Name Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End	Region	Image
Glucoheptonate	Injection, powder, lyophilized, for solution	50 mg/1	Intravenous	Anazao Health Corporation	2012-05-23	Not applicable

Over the Counter Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End	Region	Image
Calcium Liq Alsi	Liquid	125 mg / mL	Oral	Alsi Cie Ltee	1980-12-31	2003-05-21
Sirop De Calcium 625mg/5ml	Syrup	625 mg / 5 mL	Oral	Therapex Division De E Z Em Canada Inc	1980-12-31	1997-07-22

Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
Calcium Liquid	Calcium glucoheptonate (132 mg / mL) + Calcium gluconate (112 mg / mL)	Liquid	Oral	Ksl Pharmaceuticals	1994-12-31	1996-09-09
Calcium Liquid	Calcium glucoheptonate (132 mg / mL) + Calcium gluconate (112 mg / mL)	Liquid	Oral	Shoppers Drug Mart Inc.	1981-12-31	1997-08-15
Calcium Liquid	Calcium glucoheptonate (132 mg / mL) + Calcium gluconate (112 mg / mL)	Liquid	Oral	Vita Health Products Inc	1980-12-31	2002-07-31
Liquid Calcium	Calcium glucoheptonate (132 mg / mL) + Calcium gluconate (112 mg / mL)	Liquid	Oral	Wampole Brands, A Division Of Pangeo Pharma (Canada) Inc.	1998-08-12	2000-07-06

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
Glucoheptonate	Calcium glucoheptonate (50 mg/1)	Injection, powder, lyophilized, for solution	Intravenous	Anazao Health Corporation	2012-05-23	Not applicable

Chemical Identifiers

UNII: L11651398J
CAS number: 29039-00-7
InChI Key: FATUQANACHZLRT-KMRXSBRUSA-L
InChI: InChI=1S/2C7H14O8.Ca/c2*8-1-2(9)3(10)4(11)5(12)6(13)7(14)15;/h2*2-6,8-13H,1H2,(H,14,15);/q;;+2/p-2/t2*2-,3-,4+,5-,6?;/m11./s1
IUPAC Name: calcium bis((3R,4S,5R,6R)-2,3,4,5,6,7-hexahydroxyheptanoate)
SMILES: [Ca++].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)C([O-])=O

References

General References

Drop LJ, Cullen DJ: Comparative effects of calcium chloride and calcium gluceptate. Br J Anaesth. 1980 May;52(5):501-5. [Article]

External Links

Human Metabolome Database: HMDB0014471
KEGG Drug: D00934
PubChem Compound: 62859
PubChem Substance: 46507233
ChemSpider: 56591
RxNav: 47618
ChEBI: 3314
ChEMBL: CHEMBL1237066
PharmGKB: PA164746233
Wikipedia: Calcium_glucoheptonate

MSDS

Download (68.6 KB)

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count

Pharmacoeconomics

Manufacturers

Abbott laboratories pharmaceutical products div
Abraxis pharmaceutical products
Eli lilly and co

Packagers

Draxis Specialty Pharmaceuticals Inc.
Medi-Physics Inc.
Spectrum Pharmaceuticals

Dosage Forms

Form	Route	Strength
Liquid	Oral	125 mg / mL
Liquid	Oral
Injection, powder, lyophilized, for solution	Intravenous	50 mg/1
Syrup	Oral	625 mg / 5 mL

Prices

Unit description	Cost	Unit
Calcium gluceptate powder	12.69USD	g

DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.

Patents

Not Available

Properties

State

Solid

Experimental Properties

Property	Value	Source
water solubility	Soluble	Not Available

Predicted Properties

Property	Value	Source
Water Solubility	39.8 mg/mL	ALOGPS
logP	-1.9	ALOGPS
logP	-4	Chemaxon
logS	-1.1	ALOGPS
pKa (Strongest Acidic)	3.38	Chemaxon
pKa (Strongest Basic)	-3	Chemaxon
Physiological Charge	-1	Chemaxon
Hydrogen Acceptor Count	8	Chemaxon
Hydrogen Donor Count	6	Chemaxon
Polar Surface Area	161.51 Å²	Chemaxon
Rotatable Bond Count	12	Chemaxon
Refractivity	55.07 m³·mol^-1	Chemaxon
Polarizability	19.34 Å³	Chemaxon
Number of Rings	0	Chemaxon
Bioavailability	0	Chemaxon
Rule of Five	No	Chemaxon
Ghose Filter	No	Chemaxon
Veber's Rule	No	Chemaxon
MDDR-like Rule	No	Chemaxon

Predicted ADMET Features

Property	Value	Probability
Human Intestinal Absorption	-	0.9575
Blood Brain Barrier	+	0.5646
Caco-2 permeable	-	0.8513
P-glycoprotein substrate	Non-substrate	0.6616
P-glycoprotein inhibitor I	Non-inhibitor	0.9743
P-glycoprotein inhibitor II	Non-inhibitor	0.9608
Renal organic cation transporter	Non-inhibitor	0.9445
CYP450 2C9 substrate	Non-substrate	0.8702
CYP450 2D6 substrate	Non-substrate	0.87
CYP450 3A4 substrate	Non-substrate	0.7334
CYP450 1A2 substrate	Non-inhibitor	0.8579
CYP450 2C9 inhibitor	Non-inhibitor	0.9163
CYP450 2D6 inhibitor	Non-inhibitor	0.9286
CYP450 2C19 inhibitor	Non-inhibitor	0.9106
CYP450 3A4 inhibitor	Non-inhibitor	0.9274
CYP450 inhibitory promiscuity	Low CYP Inhibitory Promiscuity	0.9873
Ames test	Non AMES toxic	0.8429
Carcinogenicity	Non-carcinogens	0.838
Biodegradation	Ready biodegradable	0.9895
Rat acute toxicity	1.9804 LD50, mol/kg	Not applicable
hERG inhibition (predictor I)	Weak inhibitor	0.9838
hERG inhibition (predictor II)	Non-inhibitor	0.938

ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST): Not Available
Spectra: Not Available

Drug created at June 13, 2005 13:24 / Updated at November 03, 2023 23:40

Calcium glucoheptonate

Identification

Structure for Calcium glucoheptonate (DB00326)

Pharmacology

Interactions

Products

Categories

Chemical Identifiers

References

Clinical Trials

Pharmacoeconomics

Properties

Spectra