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Naratriptan Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126991Drug actionTriptans are a class of medications used in the treatment of migraine headaches. Triptans act as antimigraine agents by selectively binding to the serotonin receptors 5-HT1B and 5-HT1D. Triptan binding to the vascular 5-HT1B receptors le...
Drugs: ATP · Naratriptan · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acidEnzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Eletriptan Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126996Drug actionEletriptan binds with high affinity to 5-HT1B, 5-HT1D and 5-HT1F receptors, has modest affinity for 5-HT1A, 5-HT1E, 5-HT2B and 5-HT7 receptors, and little or no affinity for 5-HT2A, 5-HT2C, 5-HT3, 5-HT4, 5-HT5A and 5-HT6 receptors. In co...
Drugs: ATP · Eletriptan · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acidEnzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Edaravone
go.drugbank.com/drugs/DB12243ApprovedInvestigational[L44017] Edaravone was initially granted orphan designation by the European Medicines Agency on June 19, 2015 [L44007] and was under regulatory review in Europe. … Edaravone is a free radical scavenger and neuroprotective agent with antioxidant properties.[A254257] It has three tautomers.
Categories: Heterocyclic Compounds, 1-Ring, Compounds used in a research, industrial, or household settingSynonyms: 1-phenyl-3-methyl-5-oxo-2-pyrazoline, 3-methyl-1-phenyl-2-pyrazolin-5-oneEmpagliflozin
go.drugbank.com/drugs/DB09038ApprovedInvestigationalEmpagliflozin was further approved by the EMA in March 2022 and Health Canada in April 2022, making it the first and only approved treatment in Europe and Canada for adults with symptomatic chronic heart … [A203453] It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 diabetes mellitus.
Mixtures: GLYXAMBI® 25 MG/ 5 MG, GLYXAMBI® 10 MG/ 5 MGCategories: P-glycoprotein substrates, Sodium-Glucose Transporter 2 InhibitorsInfluenza A virus A/Brisbane/02/2018 IVR-190 (H1N1) antigen (formaldehyde inactivated)
go.drugbank.com/drugs/DB15515ApprovedA seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed, or inactivated, through exposure to heat or chemicals such as formaldehyde 3.
Mixtures: INFLUVAC S, INFLUVAC SSynonyms: Influenza A virus A/Brisbane/02/2018 IVR-190 (H1N1) antigen (formaldehyde inactivated)Sumatriptan Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126984Drug actionTriptans are a class of medications used in the treatment of migraine headaches. Triptans act as antimigraine agents by selectively binding to the serotonin receptors 5-HT1B and 5-HT1D. Triptan binding to the vascular 5-HT1B receptors le...
Drugs: ATP · Sumatriptan · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acidEnzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Gi Serotonergic Vasoconstriction
smpdb.ca/view/SMP0126992Drug actionG proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior. Their...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Zolmitriptan Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126995Drug actionZolmitriptan, like other triptans, is a serotonin (5-hydroxytryptamine; 5-HT) receptor agonist, with enhanced specificity for the 5-HT1B and 5-HT1D receptor subtypes. It is through the downstream effects of 5-HT1B/1D activation that trip...
Drugs: ATP · Zolmitriptan · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acidEnzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Rizatriptan Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126998Drug actionRizatriptan is a triptan used to treat migraines with or without aura. Rizatriptan is a second-generation triptan and a selective 5-HT1B and 5-HT1D receptor agonist. Rizatriptan is not indicated for the prophylactic therapy of migraine n...
Drugs: ATP · Rizatriptan · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acidEnzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Dihydroergotamine Mechanism of Action Action Pathway
smpdb.ca/view/SMP0127001Drug actionFirstly, DHE's s agonist action on 5-hydroxytryptamine (5HT) 1b receptors in the smooth muscle of the cranial vasculature may provide relief via vasoconstriction of the blood vessels which typically become
Drugs: ATP · Dihydroergotamine · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acidEnzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1