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Lacidipine
go.drugbank.com/drugs/DB09236ApprovedDue to its long duration of action, lacidipine does not lead to reflex tachycardia [A31536]. … Lacidipine is a lipophilic dihydropyridine calcium antagonist with an intrinsically slow onset of activity.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesMicafungin
go.drugbank.com/drugs/DB01141ApprovedInvestigationalIt belongs to the antifungal class of compounds known as echinocandins and exerts its effect by inhibiting the synthesis of 1,3-beta-D-glucan, an integral component of the fungal cell wall. … Micafungin is an antifungal drug.
Bioallethrin
go.drugbank.com/drugs/DB13746ApprovedWithdrawnA mixture of the two same stereoisomers, but in an approximate ratio of R:S in 1:3, is called esbiothrin. … Bioallethrin refers to a mixture of two of the allethrin isomers (1R,trans;1R and 1R,trans;1S) in an approximate ratio of 1:1, where both isomers are active ingredients.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesOxamniquine
go.drugbank.com/drugs/DB01096ApprovedAn anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. … Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsCamizestrant
go.drugbank.com/drugs/DB19218ApprovedInvestigational[L64094,L64107] In pre- or peri-menopausal women and in men, camizestrant plus a CDK4/6 inhibitor is combined with an LHRH agonist or antagonist. … Camizestrant is an oral selective estrogen receptor degrader (SERD) and estrogen receptor (ER) antagonist used in combination with a CDK4/6 inhibitor to treat hormone receptor-positive, HER2-negative locally
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesIndigotindisulfonic acid
go.drugbank.com/drugs/DB11577ApprovedInvestigationalThis compound is an acid-base indicator and is used in the production of food colorants and pH tests.
Gefapixant
go.drugbank.com/drugs/DB15097Approved[L48596,L48591] It is the first therapy to be approved for the treatment of RCC or UCC in the EU.[L48601] … investigation and treatment, termed refractory chronic cough (RCC) if they have a cough that does not respond to conventional treatment or unexplained chronic cough (UCC) when no diagnosable cause for the cough can
Categories: P-glycoprotein substratesBuclizine
go.drugbank.com/drugs/DB00354ApprovedBuclizine is an antihistamine medication with both antiemetic and anticholinergic effects [L6220], belonging to the _piperazine derivative_ family of drugs. … [L6217] Following this, it was touted to be effective as an appetite stimulant in children when administered in the syrup form, however, this indication has not been validated.
Synonyms: 1-(p-tert-Butylbenzyl)-4-(4-chloro-alpha-phenylbenzyl)piperazineBorneol
go.drugbank.com/drugs/DB11288ApprovedInvestigationalMixtures: Kwan Tak Hing Plaster - Pad-plsUbidecarenone
go.drugbank.com/drugs/DB09270ApprovedInvestigationalNutraceuticalUbidecarenone, also called coenzyme Q10, is a 1,4-benzoquinone. From its name (Q10), the Q refers to the constitutive quinone group, and 10 is related to the number of isoprenyl subunits in its tail. It is a powerful antioxidant, a lipid...
Mixtures: Coq10 With E400 Iu, Coen.q10w.vit.c and E Beta-car.se Cu Zn MnCategories: P-glycoprotein substrates