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Displaying results 1201 - 1210 of 10000 in total
  1. Drug

    Levoleucovorin

    go.drugbank.com/drugs/DB11596
    ApprovedInvestigational

    However, in order to function in this role, it must first be reduced by the enzyme dihydrofolate reductase (DHFR) into the cofactors dihydrofolate (DHF) and tetrahydrofolate (THF). … Folic acid is an essential B vitamin required by the body for the synthesis of purines, pyrimidines, and methionine before incorporation into DNA or protein.

    Categories: Compounds used in a research, industrial, or household setting, Vitamin B ComplexSynonyms: N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid, L-Leucovorin
  2. Drug

    Thenalidine

    go.drugbank.com/drugs/DB04826
    ApprovedWithdrawn

    Withdrawn from the Canadian, US, and UK markets in 1963 due to concerns involving neutropenia.

    Synonyms: 1-Methyl-4-amino-N-phenyl-N-(2-thenyl)piperidine, 1-Methyl-4-N-2-thenylanilinopiperidineCategories: Heterocyclic Compounds, 1-Ring
  3. Pathway

    Iodohippurate sodium I-131 Drug Metabolism

    smpdb.ca/view/SMP0130590
    Metabolic

    Iodohippurate sodium I-131 passes through the liver and is then excreted from the body mainly through the kidney. … Iodohippurate sodium I-131 is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.

    Drugs: Iodohippurate sodium I-131
  4. Pathway

    Iodohippurate sodium I-123 Drug Metabolism

    smpdb.ca/view/SMP0130602
    Metabolic

    Iodohippurate sodium I-123 passes through the liver and is then excreted from the body mainly through the kidney. … Iodohippurate sodium I-123 is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.

    Drugs: Iodohippurate sodium I-123
  5. Pathway

    Rose bengal I-131 Drug Metabolism

    smpdb.ca/view/SMP0130890
    Metabolic

    Rose bengal I-131 passes through the liver and is then excreted from the body mainly through the kidney. … Rose bengal I-131 is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.

    Drugs: Rose bengal I-131
  6. Drug

    Nedosiran

    go.drugbank.com/drugs/DB17635
    ApprovedInvestigational

    [A261685] Nedosiran was approved by the FDA on October 2<sup>nd</sup>, 2023, under the brand name RIVFLOZA to lower urinary oxalate levels in children 9 years of age and older and adults with primary … [A261690] Oxalate, particularly calcium oxalate, precipitation is the main cause of kidney stones formation; therefore, blocking the production of oxalate can help alleviate renal symptoms.

  7. Drug

    Ruxolitinib

    go.drugbank.com/drugs/DB08877
    ApprovedInvestigational

    [A229708] In 2014, it was approved for the treatment of polycythemia vera in adults who have an inadequate response to or are intolerant of [hydroxyurea] and in 2019, ruxolitinib was approved for use in … Ruxolitinib, formerly known as INCB018424 or INC424, is an anticancer drug and a Janus kinase (JAK) inhibitor.

    Categories: Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexProducts: JAKAVI 5 MG (TABLETS), JAKAVI® 10MG TABLETAS
  8. Drug

    Salicylamide

    go.drugbank.com/drugs/DB08797
    Approved

    Salicylamide is the common name for the substance o-hydroxybenzamide, or amide of salicyl. Salicylamide is a non-prescription drug with analgesic and antipyretic properties. … It has similar medicinal uses to aspirin. Salicylamide is used in combination with both aspirin and caffeine in the over-the-counter pain remedies

    Mixtures: CON-Z-LIN TABLETCategories: Non COX-2 selective NSAIDS, Analgesics, Non-Narcotic
  9. Target

    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

    go.drugbank.com/bio_entities/BE0000081
    TargetHumans

    Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. … Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

    Synonyms: Complex I-42kD
  10. Target

    Calnexin

    go.drugbank.com/bio_entities/BE0001011
    TargetHumans

    Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It...

    Synonyms: Major histocompatibility complex class I antigen-binding protein p88