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Displaying results 1201 - 1210 of 10000 in total
  1. Drug

    Pholcodine

    go.drugbank.com/drugs/DB09209
    ApprovedIllicit

    [A31742] Pholcodine is not prescribed in the United States where it is classed as a Schedule I drug. It is categorized as Class B drug in the UK and officially taken out of the shelves in 2008. … Pholcodine formula is 3-o-morpholinoethylmorphine and it is classified as an antitussive which is defined as an opioid cough suppressant.

    Mixtures: Rhynacol F SyrupCategories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds with 4 or More Rings
  2. Drug

    Rolapitant

    go.drugbank.com/drugs/DB09291
    ApprovedInvestigational

    By blocking Substance P from interacting with NK-1 receptors in the gut and the central nervous system, rolapitant prevents late-phase CINV. … Unlike other available NK-1 receptor antagonists, rolapitant is not an inhibitor of Cytochrome P450 enzyme CYP3A4 and has a long elimination half-life, allowing a single dose to prevent both acute and

    Categories: Substance P/Neurokinin-1 Receptor Antagonist, Neurokinin 1 Antagonists
  3. Drug

    Telotristat ethyl

    go.drugbank.com/drugs/DB12095
    Approved

    [L43367] Overexposure to serotonin can cause severe diarrhea, one of the main clinical symptoms of carcinoid syndrome. … [A252937] The first line treatment of carcinoid syndrome diarrhea is SSA, but symptoms still reoccur over the course of the disease.[A252937]

    Categories: Cytochrome P-450 CYP2B6 Inducers, P-glycoprotein inhibitors
  4. Drug

    Betaine

    go.drugbank.com/drugs/DB06756
    ApprovedInvestigationalNutraceutical

    However, in order to normalize homocysteine levels, patients can be treated with vitamin B6 ([pyridoxine]), vitamin B12 ([cobalamin]), [folate] and specific diets. … Currently, no treatments are available to correct the genetic causes of homocystinuria.

    Synonyms: 2-N,N,N-trimethylammonio acetate, N,N,N-TrimethylglycineMixtures: Neo Life Beta Gest Tab, Alka-pan Tablets
  5. Target

    DNA topoisomerase 1

    go.drugbank.com/bio_entities/BE0001950
    TargetEscherichia coli (strain K12)

    Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transester...

    Synonyms: DNA topoisomerase I
  6. Target

    Cytochrome c oxidase subunit 1-beta

    go.drugbank.com/bio_entities/BE0004162
    TargetParacoccus denitrificans

    Subunit I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

    Synonyms: Cytochrome c oxidase polypeptide I-beta
  7. Drug

    Nicorandil

    go.drugbank.com/drugs/DB09220
    ApprovedInvestigationalWithdrawn

    It is not an approved drug by FDA. It is a niacinamide derivative that induces vasodilation of arterioles and large coronary arteries by activating potassium channels. … Nicorandil is an orally efficacious vasodilatory drug and antianginal agent marketed in the UK, Australia, most of Europe, India, Philippines, Japan, South Korea, and Taiwan.

    Synonyms: N-(2-Hydroxyethyl)nicotinamide nitrate, N-(2-Hydroxyethyl)nicotinamide nitrate (ester)International brands: K-Cor
  8. Drug

    Lorlatinib

    go.drugbank.com/drugs/DB12130
    ApprovedInvestigational

    It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-positive non-small cell lung cancer, followed by an expanded approval in 2022 to … Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer[L39905] which was first approved by the US FDA in November of 2018

    Categories: MATE 1 Inhibitors, P-glycoprotein inducersProducts: LORBRENA® 25 MG, LORBRENA® 100 MG
  9. Target

    COUP transcription factor 1

    go.drugbank.com/bio_entities/BE0008953
    TargetHumans

    Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of th...

    Synonyms: COUP-TF I, COUP transcription factor I
  10. Drug

    Belantamab mafodotin

    go.drugbank.com/drugs/DB15719
    ApprovedInvestigationalWithdrawn

    [L44236] In July of 2025, belantamab mafodotin was approved by Health Canada for a similar indication, but for use in combination with either [Dexamethasone] and [Bortezomib] or [Dexamethasone] and [Pomalidomide … US marketing authorization in November 2022.

    Categories: P-glycoprotein substrates