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Iodohippurate sodium I-123 Drug Metabolism
smpdb.ca/view/SMP0130602MetabolicIodohippurate sodium I-123 passes through the liver and is then excreted from the body mainly through the kidney. … Iodohippurate sodium I-123 is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.
Drugs: Iodohippurate sodium I-123Rose bengal I-131 Drug Metabolism
smpdb.ca/view/SMP0130890MetabolicRose bengal I-131 passes through the liver and is then excreted from the body mainly through the kidney. … Rose bengal I-131 is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.
Drugs: Rose bengal I-131Omalizumab
go.drugbank.com/drugs/DB00043ApprovedInvestigationalBy binding to IgE and neutralizing it, omalizumab reduces free IgE levels and prevents IgE from binding to its receptors on immune cells. … [A39518] Omalizumab was first approved in the US in 2003 [A263507] and in Europe in 2005.
Categories: Agents to Treat Airway DiseaseProducts: XOLAIR SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE 150MG/1.0ML, XOLAIR SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE 75MG/0.5MLLevoleucovorin
go.drugbank.com/drugs/DB11596ApprovedInvestigationalHowever, in order to function in this role, it must first be reduced by the enzyme dihydrofolate reductase (DHFR) into the cofactors dihydrofolate (DHF) and tetrahydrofolate (THF). … Folic acid is an essential B vitamin required by the body for the synthesis of purines, pyrimidines, and methionine before incorporation into DNA or protein.
Categories: Compounds used in a research, industrial, or household setting, Vitamin B ComplexSynonyms: N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid, L-LeucovorinNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
go.drugbank.com/bio_entities/BE0000081TargetHumansAccessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. … Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Synonyms: Complex I-42kDCalnexin
go.drugbank.com/bio_entities/BE0001011TargetHumansCalcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It...
Synonyms: Major histocompatibility complex class I antigen-binding protein p88Tryptase alpha/beta-1
go.drugbank.com/bio_entities/BE0003736TargetHumansIsoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates (PubMed:18854315)
Synonyms: Tryptase ICytochrome c oxidase subunit 1
go.drugbank.com/bio_entities/BE0004055TargetRhodobacter sphaeroidesCo I is the catalytic subunit of the enzyme.
Synonyms: Cytochrome c oxidase polypeptide IThenalidine
go.drugbank.com/drugs/DB04826ApprovedWithdrawnWithdrawn from the Canadian, US, and UK markets in 1963 due to concerns involving neutropenia.
Categories: Heterocyclic Compounds, 1-RingSynonyms: 1-Methyl-4-amino-N-phenyl-N-(2-thenyl)piperidine, 1-Methyl-4-N-2-thenylanilinopiperidineRuxolitinib
go.drugbank.com/drugs/DB08877ApprovedInvestigational[A229708] In 2014, it was approved for the treatment of polycythemia vera in adults who have an inadequate response to or are intolerant of [hydroxyurea] and in 2019, ruxolitinib was approved for use in … Ruxolitinib, formerly known as INCB018424 or INC424, is an anticancer drug and a Janus kinase (JAK) inhibitor.
Categories: Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexProducts: JAKAVI 5 MG (TABLETS), JAKAVI® 10MG TABLETAS