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Displaying results 1211 - 1220 of 10000 in total
  1. Drug

    Sofpironium

    go.drugbank.com/drugs/DB19325
    Approved

    [L51109] Soft drugs are designed to reduce systemic toxicity while enhancing local efficacy by employing retrometabolic drug design, in which a molecule contains a metabolically sensitive moiety that promotes … Sofpironium is a "soft" anticholinergic analog of [glycopyrronium] that has been modified with a readily hydrolyzable ester moiety.

    Synonyms: Pyrrolidinium, 3-(((2r)-2-cyclopentyl-2-hydroxy-2-phenylacetyl)oxy)-1-(2-ethoxy-2-oxoethyl)-1-methyl-, (3r)-Categories: MATE 1 Inhibitors, Heterocyclic Compounds, 1-Ring
  2. Drug

    Ethinamate

    go.drugbank.com/drugs/DB01031
    ApprovedIllicitWithdrawn

    Like many such similar medications, the regular use of ethinamate can result in the development of drug tolerance in a patient. … Ethinamate is a short-acting sedative-hypnotic medication used to treat insomnia.

    Synonyms: 1-ethynylcyclohexanol carbamate
  3. Drug

    (2S,3S)-4-cyclopropyl-3-{(3R,5R)-3-[2-fluoro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazolidin-5-yl}-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine

    go.drugbank.com/drugs/DB06993
    Experimental

    Synonyms: (2S,3S)-4-cyclopropyl-3-{(3R,5R)-3-[2-fluoro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazolidin-5-yl}-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
  4. Drug

    Vinflunine

    go.drugbank.com/drugs/DB11641
    ApprovedInvestigational

    Vinflunine is a third-generation member of the vinca alkaloid family with anti-tumour actions. It was first described in 1998 at the Pierre Fabre research center in France. … Like other vinca agents, vinflunine is an anti-mitotic agent that induces a cell cycle arrest at the G2/M phase and promotes cell death via apoptosis [L1396].

    Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexSynonyms: 4'-deoxy-20',20'-difluoro-5'-norvincaleukoblastine, 20',20'-difluoro-3',4'-dihydrovinorelbine
  5. Drug

    D-Gluco-2,5-Anhydro-1-Deoxy-1-Phosphonohexitol-6-Phosphate

    go.drugbank.com/drugs/DB02393
    Experimental

    Synonyms: D-Gluco-2,5-Anhydro-1-Deoxy-1-Phosphonohexitol-6-Phosphate
  6. Drug

    3'-1-carboxy-1-phosphonooxy-ethoxy-uridine-diphosphate-N-acetylglucosamine

    go.drugbank.com/drugs/DB04174
    Experimental

    Synonyms: 3'-1-carboxy-1-phosphonooxy-ethoxy-uridine-diphosphate-N-acetylglucosamine
  7. Drug

    Tripotassium (1R)-4-biphenyl-4-yl-1-phosphonatobutane-1-sulfonate

    go.drugbank.com/drugs/DB07424
    Experimental

    Synonyms: Tripotassium (1R)-4-biphenyl-4-yl-1-phosphonatobutane-1-sulfonate
  8. Drug

    Naloxone

    go.drugbank.com/drugs/DB01183
    ApprovedInvestigationalVet approved

    [A234594] More specifically, naloxone has a high affinity for μ-opioid receptors, where it acts as an inverse agonist, causing the rapid removal of any other drugs bound to these receptors. … [L33734] Kits commonly include the supplies necessary to treat an overdose in a non-medical setting such as alcohol swabs, syringes, a rescue breathing mask, and instructions for use.

    Mixtures: Bupensan Duo 4 mg/1 mg-Sublingualtabletten, TARGIN (R) 10 MG / 5 MG TABLETAS DE LIBERACIÓN PROLONGADACategories: P-glycoprotein substrates, Cytochrome P-450 Substrates
  9. Drug

    Metronidazole benzoate

    go.drugbank.com/drugs/DB15759
    Investigational

    Mixtures: METRONIDAZOL BENZOILO/ NIFUROXAZIDA 250MG + 200MG/5 ML SUSPENSION, DIARSET NX- M SUSPENSIONCategories: Heterocyclic Compounds, 1-Ring
  10. Drug

    1-[5-Methyl-2-(trifluoromethyl)furan-3-yl]-3-[5-[2-[[6-(1H-1,2,4-triazol-5-ylamino)pyrimidin-4-yl]amino]ethyl]-1,3-thiazol-2-yl]urea

    go.drugbank.com/drugs/DB07789
    Experimental

    Synonyms: 1-[5-Methyl-2-(trifluoromethyl)furan-3-yl]-3-[5-[2-[[6-(1H-1,2,4-triazol-5-ylamino)pyrimidin-4-yl]amino]ethyl]-1,3-thiazol-2-yl]urea