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Equine Botulinum Neurotoxin B Immune FAB2
go.drugbank.com/drugs/DB13903ApprovedIt is intravenously administered for the treatment of symptomatic botulism following documented or suspected exposure to botulinum neurotoxin serotypes B in adults and pediatric patients. … Equine Botulinum Neurotoxin B Immune FAB2 is composed of a mixture of immune globulin fragments purified from plasma of horses that were previously immunized with botulinum toxin serotype B.
Nonoxynol-9
go.drugbank.com/drugs/DB06804ApprovedWithdrawnNonoxynol-9 (N-9) is a typical surfactant used as a vaginal spermicide. Spermicides are locally acting non-hormonal contraceptives. … N-9 has been in use for more than 30 years as an over-the-counter (OTC) drug in creams, gels, foams and condom lubricants.
Categories: Compounds used in a research, industrial, or household setting, Hormonal Contraceptives for Systemic UseTapentadol
go.drugbank.com/drugs/DB06204ApprovedInvestigationalTapentadol is a centrally-acting synthetic analgesic with a dual mechanism of action. It is a mu-opioid receptor agonist that also inhibits norepinephrine reuptake. … [L47291] Used in the management of pain, tapentadol is typically reserved for patients who have limited alternative treatment options.
Netarsudil
go.drugbank.com/drugs/DB13931ApprovedInvestigationalsolution) 0.02% for the indication of reducing elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. … Acting as both a rho kinase inhibitor and a norepinephrine transport inhibitor, Netarsudil is a novel glaucoma medication in that it specifically targets the conventional trabecular pathway of aqueous
Bulevirtide
go.drugbank.com/drugs/DB15248ApprovedInvestigational[A226305] Bulevirtide, also known as Hepcludex, is a first-in-class entry inhibitor for the treatment of chronic Hepatitis D infection developed by MYR Pharmaceuticals, now part of Gilead. … [A226340,L30235] Until recently, there have been extremely limited treatments available for Hepatitis D infection.
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic UseNitroglycerin
go.drugbank.com/drugs/DB00727ApprovedInvestigational[A180166,A180172] Its use as a treatment for angina dates back to 1879 and is still used to treat and prevent angina.[A249970] Nitroglycerin causes vasodilation in both arteries and veins. … Nitroglycerin, also known as glyceryl trinitrate,[A180169] is an organic nitrate and a vasodilating agent [L38369] that was first discovered in 1847.
Categories: Compounds used in a research, industrial, or household setting, Agents for Treatment of Hemorrhoids and Anal Fissures for Topical UseProducts: GLYDEX IV Solution for Injection 1mg/ml, NITROGLICERINA EN DEXTROSA AL 5% 50MG/250MLPiflufolastat F 18
go.drugbank.com/drugs/DB14805ApprovedInvestigational[A235169] As such, it has become a desirable target for PET imaging of prostate cancer tissues. … Piflufolastat F18, also called [F-18]-DCFPyL, is a urea-based radiopharmaceutical that binds to PSMA and allows for the visualization of cancerous prostate tissue.
Rezafungin
go.drugbank.com/drugs/DB16310ApprovedInvestigationalRezafungin has a half-life higher than 130 hours and can be administered once a week instead of daily. … [A258393,L45633] Unlike other echinocandins such as [caspofungin] and [micafungin], rezafungin has long‐acting pharmacokinetics and a high stability that allows for it to have long dosing intervals maintaining
Synonyms: Echinocandin B, 1-((4R,5R)-4-hydroxy-N2-((4''-(pentyloxy)(1,1':4',1''-terphenyl)-4-yl)carbonyl)-5-(2-(trimethylammonio)ethoxy)-l-ornithine)-4-((4S)-4-hydroxy-4-(4-hydroxyphenyl)-l-allothreonine)-Kappadione
go.drugbank.com/drugs/DB09332ApprovedKappadione is a Vitamin K derivative (chemically, it is menadiol sodium diphosphate), previously approved by FDA prior to 1982 and marketed by Lilly Marketing for this drug has been discontinued and is … Studies involving the active metabolite of this formulation, menadione, showed oocyte toxicity in a study of mice [L1544].
Anethole trithione
go.drugbank.com/drugs/DB13853ApprovedAnethole trithione (ATT) appears to have a broad range of unique functions, from increasing salivary secretion to help treat xerostomia [A27165, A32618, A32620, A32621], to demonstrating an ability to … inhibit carcinogenesis by increasing the activity of electrophile detoxification enzymes [A32619], and even being used as an adjunctive therapy for cholecystitis, gallstone, indigestion, and acute/chronic