DCFPyL F-18

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
DCFPyL F-18
Accession Number
DB14805
Description

DCFPyL F-18 is under investigation in clinical trial NCT02691169 (Integrated 18F-labelled PSMA Project).

Type
Small Molecule
Groups
Investigational
Structure
Thumb
Weight
Average: 441.403
Monoisotopic: 441.152526384
Chemical Formula
C18H23FN4O8
Synonyms
  • 18F-DCFPYL

Pharmacology

Indication
Not Available
Contraindications & Blackbox Warnings
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Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

Categories

Drug Categories
Not Available
Classification
Not classified

Chemical Identifiers

UNII
3934EF02T7
CAS number
1207181-29-0
InChI Key
OLWVRJUNLXQDSP-MVBOSPHXSA-N
InChI
InChI=1S/C18H23FN4O8/c19-13-6-4-10(9-21-13)15(26)20-8-2-1-3-11(16(27)28)22-18(31)23-12(17(29)30)5-7-14(24)25/h4,6,9,11-12H,1-3,5,7-8H2,(H,20,26)(H,24,25)(H,27,28)(H,29,30)(H2,22,23,31)/t11-,12-/m0/s1/i19-1
IUPAC Name
(2S)-2-({[(1S)-1-carboxy-5-{[6-(¹⁸F)fluoropyridin-3-yl]formamido}pentyl]carbamoyl}amino)pentanedioic acid
SMILES
OC(=O)CC[[email protected]](NC(=O)N[[email protected]@H](CCCCNC(=O)C1=CC=C([18F])N=C1)C(O)=O)C(O)=O

References

General References
Not Available
ChemSpider
32702072

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedDiagnosticAdenocarcinoma, Prostate / Metastatic Hormone Refractory Prostate Cancer / Prostate Cancer / Recurrent Prostate Cancer1
2CompletedDiagnosticProstate Cancer1
2Not Yet RecruitingDiagnosticBreast Cancer / HER2 Negative Breast Cancer / HER2-Negative Breast Cancer / Metastatic Breast Cancer1
2Not Yet RecruitingOtherGenital Diseases, Male / Genital Neoplasms, Male / Genitourinary tract neoplasm / Neoplasms / Neoplasms by Site / Prostatic Diseases / Prostatic Neoplasms1
2RecruitingDiagnosticCastrate Sensitive Prostate Cancer1
2RecruitingDiagnosticGynecologic Cancers1
2RecruitingDiagnosticMetastatic Hormone Refractory Prostate Cancer / Prostate Cancer / Prostate Neoplasms1
2RecruitingDiagnosticMetastatic Hormone Refractory Prostate Cancer / Prostate Cancer / Prostate Neoplasms / Prostatic Neoplasms1
2RecruitingDiagnosticProstate Cancer3
2RecruitingDiagnosticRenal Cell Adenocarcinoma1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.191 mg/mLALOGPS
logP-0.37ALOGPS
logP-0.32ChemAxon
logS-3.4ALOGPS
pKa (Strongest Acidic)2.99ChemAxon
Physiological Charge-3ChemAxon
Hydrogen Acceptor Count9ChemAxon
Hydrogen Donor Count6ChemAxon
Polar Surface Area195.02 Å2ChemAxon
Rotatable Bond Count13ChemAxon
Refractivity101.38 m3·mol-1ChemAxon
Polarizability42 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on May 20, 2019 08:28 / Updated on June 12, 2020 10:53

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