Search
Pyruvate oxidase
go.drugbank.com/bio_entities/BE0001354TargetEnzymeLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)Important for the aerobic growth. Decarboxylates pyruvate in four steps. The energy released is partially stored in acetyl phosphate.
Synonyms: POXRNA-directed RNA polymerase lambda-3
go.drugbank.com/bio_entities/BE0004792TargetT3DRNA-directed RNA polymerase that is involved in transcription and genome replication. Following infection, it catalyzes the synthesis of fully conservative plus strands. After core assembly, which consists in recruitment of one capped pl...
Synonyms: Lambda3(Pol)Tenia Solium Infection
go.drugbank.com/conditions/DBCOND0056943Drugs: MebendazoleSynonyms: Pork tapeworm infection, Tapeworm infection: [intestinal taenia solium] or [pork]Levallorphan
go.drugbank.com/drugs/DB00504ApprovedIt should be used cautiously; levallorphan reverses severe opioid-induced respiratory depression but may exacerbate respiratory depression such as that induced by alcohol or other non-opioid central depressants
Categories: Heterocyclic Compounds with 4 or More RingsKappadione
go.drugbank.com/drugs/DB09332ApprovedKappadione is a Vitamin K derivative (chemically, it is menadiol sodium diphosphate), previously approved by FDA prior to 1982 and marketed by Lilly Marketing for this drug has been discontinued and is … Studies involving the active metabolite of this formulation, menadione, showed oocyte toxicity in a study of mice [L1544].
Serplulimab
go.drugbank.com/drugs/DB17451ApprovedInvestigationalIt was first approved in China - where it is indicated for a number of different cancers[L52963] - and has since been approved in several southeast Asian countries. … Most recently, it was approved in the EU in February 2025 for the treatment of extensive-stage small cell lung cancer.[L52968,L52953]
Categories: PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitorsAcalabrutinib
go.drugbank.com/drugs/DB11703ApprovedInvestigational/and that fill an unmet medical need based on a surrogate endpoint. … [L10241] In August 2022, the FDA approved a new tablet formulation of Calquence, enabling the co-administration of this drug with proton pump inhibitors (PPIs).
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexAzilsartan medoxomil
go.drugbank.com/drugs/DB08822ApprovedInvestigationalIt is used to treat hypertension as monotherapy or in combination with other antihypertensive drugs. It is also available in a combination product with [chlorthalidone]. … As hypertension is a major risk factor for cardiovascular disease,[A7354] early management of hypertension has several implications on patients' survival rate and quality of life in the future.
Categories: Antihypertensive Agents Indicated for HypertensionVenlafaxine
go.drugbank.com/drugs/DB00285ApprovedInvestigationalIt was also considered a second-line treatment for obsessive-compulsive disorder (OCD). … [A252065] Venlafaxine has been used as a first-line treatment for MDD, GAD, social anxiety disorder, and panic disorder in Canada for many years.
Categories: Antidepressive Agents Indicated for DepressionProducts: VENLAFAXIN AL 75MG REK, VENLAFAXIN 1A 75MG REKUbrogepant
go.drugbank.com/drugs/DB15328ApprovedInvestigational[L10959] Several oral small molecule CGRP receptor antagonists, belonging to a class of medications referred to as "gepants", have been investigated for migraines, but only ubrogepant and [rimegepant] … Ubrogepant is indicated for the acute treatment of migraine headaches with or without aura in adults.
Categories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates