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Nitrofurantoin
go.drugbank.com/drugs/DB00698ApprovedInvestigationalVet approved[A179824] Nitrofurantoin is a second line treatment to [trimethoprim]/[sulfamethoxazole].[A179830] Nitrofurantoin was granted FDA approval on 6 February 1953.[L6895] … [A179824] This drug is more resistant to the development of bacterial resistance because it acts on many targets at once.
Synonyms: N-(5-Nitrofurfurylidene)-1-aminohydantoinProducts: Nu-nitrofurantoin TabletsAcetyl sulfisoxazole
go.drugbank.com/drugs/DB14033ApprovedVet approvedThis process causes an inhibition of bacterial folic acid synthesis and de novo synthesis of purines and pyrimidines, resulting in cell growth arrest and cell death [L2788]. … Sulfisoxazole acetyl is an ester of _sulfisoxazole_, a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with antibacterial activity.
Phenoxyethanol
go.drugbank.com/drugs/DB11304ApprovedInvestigationalIt is produced by reacting phenol (EU) and ethylene oxide (EU) at a high temperature and pressure. This substance occurs naturally in green tea (EU) [L2621]. … Phenoxyethanol (EU), or PE, is the most commonly used globally-approved preservative in personal care formulations. It is very easy to use in various types of formulations and is chemically stable.
Aminophylline
go.drugbank.com/drugs/DB01223ApprovedInvestigationalThe majority of aminophylline medications are discontinued and the remaining medications on the market are in short supply. … Aminophylline is a drug combination that contains theophylline and ethylenediamine in a 2:1 ratio.
Categories: Compounds used in a research, industrial, or household settingLevoleucovorin
go.drugbank.com/drugs/DB11596ApprovedInvestigationalThis important pathway, which is required for de novo synthesis of nucleic acids and amino acids, is disrupted when high-dose methotrexate is used for cancer therapy. … effects (Kovoor et al, 2009).
Categories: Compounds used in a research, industrial, or household settingSynonyms: N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acidOxaliplatin
go.drugbank.com/drugs/DB00526ApprovedInvestigational[A796,A797] This is an effective combination treatment both as a first-line treatment and in patients refractory to an initial fluorouracil and leucovorin combination. … [A260396] However, due to the structure of oxaliplatin, its adducts make the binding of mismatch repair protein to DNA harder compared to cisplatin or carboplatin's adducts, resulting in greater cytotoxic
Synonyms: (SP-4-2-(1R-TRANS))-(1,2-CYCLOHEXANEDIAMINE-N,N')(ETHANEDIOATO(2-)-O,O')PLATINUMCholine salicylate
go.drugbank.com/drugs/DB14006ApprovedNutraceuticalThe UK government has regulated its use, due to toxicity in those under 16 years of age. … This drug is also a main ingredient in teething gels to relieve pains associated with tooth growth in the infant population [L2134].
Osilodrostat
go.drugbank.com/drugs/DB11837ApprovedInvestigational[A191850] Osilodrostat was approved for use in the EU in January 2020 for the treatment of endogenous Cushing's syndrome (i.e. … [A191910] As an orally bioavailable drug therapy, osilodrostat provides a novel treatment option for patients in whom removal of the causative tumor is not an option or for whom previous pituitary surgery
Estradiol cypionate
go.drugbank.com/drugs/DB13954ApprovedVet approvedof hypoestrogenism due to hypogonadism [FDA Label]. … in potency and in estrogenic effects.
Thymidine
go.drugbank.com/drugs/DB04485ApprovedInvestigationaltoxicity of established anti-metabolite chemotherapeutic agents, such as 5-Fluorouracil (FU), Methotrexate (MTX), and Cytosine arabinoside (ara-C). … [A274683, A274688] As of now, its primary role is in research and as a sensitizer or modulator in experimental chemotherapy regimens, rather than a standalone, approved therapeutic agent.
Synonyms: -D-erythro-pentofuranosyl)-5-methyl-, -D-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione