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Gramicidin D
go.drugbank.com/drugs/DB00027ApprovedInvestigationalGramcidins are 15 residue peptides with alternating D and L amino acids, which assemble inside of the hydrophobic interior of the cellular lipid bilayer to form a β-helix. … Gramcidin D is a heterogeneous mixture of three antibiotic compounds, gramicidins A, B and C, making up 80%, 6%, and 14% respectively all of which are obtained from the soil bacterial species Bacillus
Mixtures: IQFAIN-OF, Kenacomb OntSynonyms: Gramicidin D, Bacillus brevis gramicidin DFormaldehyde
go.drugbank.com/drugs/DB03843ApprovedVet approvedIn solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. … A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons.
Categories: Compounds used in a research, industrial, or household settingChorionic Gonadotropin (Human)
go.drugbank.com/drugs/DB09126ApprovedInvestigationalVet approvedEndogenously produced HCG interacts with the LHCG receptor of the ovary and promotes the maintenance of the corpus luteum during the beginning of pregnancy. … HCG is composed of an alpha and a beta sub-unit.
Categories: Sex Hormones and Modulators of the Genital SystemProducts: Apl Inj 1000 Iu/ml, PREGNYL INJECTION 5000 IUNevirapine
go.drugbank.com/drugs/DB00238ApprovedInvestigationalA potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS.
Mixtures: ZIMODINE N ®, LAVUZID® NCategories: Inducers of Drug Clearance, Antivirals used in combination for the treatment of HIV infectionsTapentadol
go.drugbank.com/drugs/DB06204ApprovedInvestigational[A260721, A36596] Tapentadol was first approved by the FDA on November 20, 2008. The extended-release formulation of tapentadol was also approved by the FDA on August 26, 2011. … Tapentadol is a centrally-acting synthetic analgesic with a dual mechanism of action. It is a mu-opioid receptor agonist that also inhibits norepinephrine reuptake.
Categories: Combined Inhibitors of Serotonin/Norepinephrine Reuptake, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeIdebenone
go.drugbank.com/drugs/DB09081ApprovedInvestigationalDue to its biochemical mode of action, it's thought that idebenone may re-activate viable-but-inactive retinal ganglion cells (RGCs) in LHON patients [L885]. … Idebenone is a synthetic analogue of ubiquinone (also known as Coenzyme Q10), a vital cell antioxidant and essential component of the Electron Transport Chain (ETC).
Categories: Compounds used in a research, industrial, or household settingMetaxalone
go.drugbank.com/drugs/DB00660ApprovedInvestigationalMetaxalone is a moderate to strong muscle relaxant used in the symptomatic treatment of musculoskeletal pain caused by strains, sprains, and other musculoskeletal conditions. … Its main mechanism of action is thought to involve general central nervous system depression. Metaxalone is associated with few side effects and is available as a 800 mg scored tablet.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeAbiraterone
go.drugbank.com/drugs/DB05812ApprovedInvestigational[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April,[A260880] July,[L47745] and September 2011,[A260880] respectively. … Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis
Categories: Metabolic Side Effects of Drugs and SubstancesSynonyms: 17-(3-Pyridyl)androsta-5,16-dien-3beta-ol, (3β)-17-(pyridin-3-yl)androsta-5,16-dien-3-olCanagliflozin
go.drugbank.com/drugs/DB08907ApprovedInvestigationalIt was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 for a second indication of reducing the risk of cardiovascular events in patients diagnosed with type … Cardiovascular disease is the most common cause of death in these patients [A177083].
Mixtures: INVOKANA DUOCategories: Drugs Used in DiabetesCollagenase clostridium histolyticum
go.drugbank.com/drugs/DB00048ApprovedInvestigational[L14882] The topical formulation is used for the debridement of necrotic tissue due to burns or chronic ulcers. … [L14912] On July 6, 2020 a combination of injectable bacterial collagenases was approved by the FDA for the treatment of cellulite in adult women.
Categories: Preparations for Treatment of Wounds and Ulcers