Metaxalone

DB00660ApprovedInvestigationalSmall moleculeMuscle Relaxants

Metaxalone is a muscle relaxant used to treat muscle pain or spasm. It is marketed by King Pharmaceuticals under the brand name Skelaxin®.

Chemical structure of Metaxalone
Mechanism
Curator reviewed
Primary indication
For the treatment of painful peripheral musculoskeletal conditions and spasticity from upper motor neuron syndromes.Curator reviewed · 1 structured indication
Formula / weight
C12H15NO3 · 221.2524 g/mol (avg)
First approval
United States, 1962
Code names
AHR 438
Brand names
  • Metaxal
  • Skelaxin

Resolves to

Compound
UNII1NMA9J598YCAS1665-48-1ChEMBLCHEMBL1079604ChEBI6797PubChem15459KEGGD00773
Clinical / RWD
RxNorm59078PharmGKBPA164747189
Structure
InChIKeyIMWZZHHPURKASS-UHFFFAOYSA-NSMILESCC1=CC(OCC2CNC(=O)O2)=CC(C)=C1
Targets
P21397MAOA

What you can answer from here — as of September 11, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
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1,614Drug interactionsStructured to mechanism, not free text
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8Clinical trialsPhase, status and sponsor resolved per trial
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1Structured indicationCondition, population, route and combination as fields, not prose
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158Marketed productsAcross 1 country and 68 labellers
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5+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Metaxalone, and which of those have an active Phase 3 trial?

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