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Ivabradine
go.drugbank.com/drugs/DB09083ApprovedInvestigationalIvabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart failure in patients with an ejection fraction of ≤35%, in sinus rhythm with resting heart rate … Ivabradine acts by selectively inhibiting the "funny" channel pacemaker current (If) in the sinoatrial node in a dose-dependent fashion, resulting in a lower heart rate and thus more blood to flow to the
Mixtures: IMPLICOR 25MG/5MG FILM-COATED TABLETS, IMPLICOR 50MG/5MG FILM-COATED TABLETSCategories: metoprolol and ivabradine, carvedilol and ivabradineQuinidine
go.drugbank.com/drugs/DB00908ApprovedThis alkaloid was first described in 1848 and has a long history as an antiarrhythmic medication. … [A38016] It prolongs cellular action potential by blocking sodium and potassium currents.
Mixtures: Dextromethorphan hydrobromide and quinidine sulfate, Dextromethorphan Hydrobromide and Quinidine SulphateCategories: Quinine and stereoisomer, Metabolic Side Effects of Drugs and SubstancesPotassium bicarbonate
go.drugbank.com/drugs/DB11098ApprovedInvestigationalPotassium bicarbonate is a white, crystalline, slightly alkaline and salty substance. It is produced by the passage of carbon dioxide through an aqueous potassium carbonate solution. … It is used in medicine as an antacid.[T141] It is registered in the FDA under the section of suitable, safe and effective ingredients for OTC antacids.
Mixtures: Buffered Vitamin C Pwr W Cal-mag-potassium, Coenzyme Q10 Isotonix Vitamin and Mineral SupplementCategories: Alimentary Tract and MetabolismApomorphine
go.drugbank.com/drugs/DB00714ApprovedInvestigational[A203618] Apomorphine has also been investigated as an emetic, a sedative, a treatment for alcoholism, and a treatment of other movement disorders. … Apomorphine is a non-ergoline dopamine D2 agonist indicated to treat hypomobility associated with Parkinson's. It was first synthesized in 1845 and first used in Parkinson's disease in 1884.
Categories: Drugs Used in Erectile Dysfunction, Genito Urinary System and Sex HormonesProducts: APOKINON ® 5MG/ MLSOLUCION INYECTABLE, APO-GO PFS 5MG/ML SC INFÜZYONLUK ÇÖZELTI IÇEREN KULLANIMA HAZIR ŞIRINGA, 5 ŞIRINGAProtein C
go.drugbank.com/drugs/DB11312ApprovedInvestigationalAPC exerts its effect by inactivating essential components of the coagulation cascade (specifically factors V and VIII), which leads to a decrease in thrombin formation, and therefore a reduction in clot … Protein C is an endogenously occurring plasma protein that plays a key role within the coagulation cascade.
Mixtures: OCTAPLEX POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 500 IU, Octaplex Powder and Solvent for Solution for InfusionCategories: Enzymes and Coenzymes, Blood and Blood Forming OrgansLeuprolide
go.drugbank.com/drugs/DB00007ApprovedInvestigational[L13850] Since this initial approval, various long-acting intramuscular and subcutaneous products have been developed such that patients can be dosed once every six months. … [A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename Lupron™ by Abbvie Endocrine Inc.
Categories: Hormones and Related Agents, Amino Acids, Peptides, and ProteinsProducts: POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 45mg, POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 7.5mgSufentanil
go.drugbank.com/drugs/DB00708ApprovedInvestigationalSufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. … It is administered by the intravenous, epidural and sublingual routes.
Categories: Fentanyl and fentanyl analoguesSynonyms: N-(4-(Methoxymethyl)-1-(2-(2-thienyl)ethyl)-4-piperidinyl)-N-phenylpropanamide, N-(4-(Methoxymethyl)-1-(2-(2-thienyl)ethyl)-4-piperidyl)propionanilidePegfilgrastim
go.drugbank.com/drugs/DB00019ApprovedInvestigational[A187607] First developed by Amgen, pegfilgrastim was initially approved by the FDA in 2002 and marketed as Neulasta. It is typically administered via a subcutaneous injection. … [L9779,L9785,L43050] These biosimilars are highly similar to the reference product, Neulasta, in terms of pharmacological and pharmacokinetic profile and conditions of use.
Categories: Compounds used in a research, industrial, or household setting, Amino Acids, Peptides, and ProteinsProducts: Pelgraz 6 mg solution for injection in a pre-filled syringe, Pelgraz Solution for Injection in pre-filled syringe 6mg/0.6mLAllopurinol
go.drugbank.com/drugs/DB00437ApprovedInvestigationalIt was initially approved by the FDA in 1966 [L5674] and is now formulated by several manufacturers [L5677]. … This disease has been well-documented in historical medical records and appears in the biographies of several prominent, historically recognized individuals [A175942].
Products: CLINT TABLET 100MG, Purinol Tab 100mgChromium
go.drugbank.com/drugs/DB11136ApprovedInvestigationalHumans can be exposed to chromium via ingestion, inhalation, and dermal or ocular exposure [L1983]. … Trivalent chromium (Cr(III)) ion is considered to be an essential dietary trace element as it is involved in metabolism of blood glucose, regulation of insulin resistance and metabolism of lipids.
Mixtures: Spark Cap, Diacomp - CapCategories: Diet, Food, and Nutrition