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Tolcapone
go.drugbank.com/drugs/DB00323ApprovedInvestigationalWithdrawnIt is a yellow, odorless, non-hygroscopic, crystalline compound. Tolcapone is associated with a risk of hepatotoxicity. … Tolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase (COMT). It is used in the treatment of Parkinson's disease as an adjunct to levodopa/carbidopa medication.
Acid Cholesteryl Ester Hydrolase Deficiency, Wolman Type
go.drugbank.com/conditions/DBCOND0076044Drugs: Sebelipase alfaSynonyms: Acid esterase deficiency, Deficiency of cholesterol esterase and triacylglycerol lipaseAcute attacks of hereditary angioedema
go.drugbank.com/conditions/DBCOND0024027Drugs: Berotralstat · Conestat alfa · Donidalorsen · Ecallantide · Garadacimab · Human C1-esterase inhibitor +3 moreSynonyms: C1 Esterase Inhibitor Deficiency, C-1 esterase inhibitor deficiencyInsulin glargine
go.drugbank.com/drugs/DB00047ApprovedInvestigationalcells that the body is no longer able to produce insulin on its own. … [L34964] Insulin glargine is produced by recombinant DNA technology using a non-pathogenic laboratory strain of Escherichia coli (K12) as the production organism.
Ferric pyrophosphate citrate
go.drugbank.com/drugs/DB13995ApprovedThe ferric ion is strongly complexed by pyrophosphate and citrate.[A31979] FPC is categorized in Japan as a second class OTC drug. … [L1420] This category is given to drugs with ingredients that in rare cases may cause health problems requiring hospitalization or worst.[L1419] It is also FDA approved since 2015.[FDA label]
Sipuleucel-T
go.drugbank.com/drugs/DB06688ApprovedInvestigationalThe treatment initially cost $93,000 at the time of FDA approval, but rose to over $100,000 in 2014. … Sipuleucel-T was approved by the U.S. Food and Drug Administration (FDA) on April 29, 2010, to treat asymptomatic or minimally symptomatic metastatic Hormone-Refractory Prostate Cancer (HRPC).
Inulin
go.drugbank.com/drugs/DB00638ApprovedInvestigationalNutraceuticalSince it is hydrolyzable to fructose, it is classified as a fructosan. It has been used in physiologic investigation for determination of the rate of glomerular function.
Digoxin
go.drugbank.com/drugs/DB00390ApprovedInvestigational[A178234] Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. … [L9143] This drug originates from the foxglove plant, also known as the _Digitalis_ plant[T610], studied by William Withering, an English physician and botanist in the 1780s.
Bempedoic acid
go.drugbank.com/drugs/DB11936ApprovedInvestigational[L12144,L12147] It was developed by Esperion Therapeutics Inc. and approved by the FDA on February 21, 2020. … Caused by genetic mutations or lifestyle factors, hypercholesterolemia can significantly reduce quality of life and increase the risk of mortality from cardiovascular disease.
Categories: Non-statin Hypolipidemic Agents Indicated for HyperlipidemiaBelladonna
go.drugbank.com/drugs/DB13913ApprovedThe name "belladonna" originates from the Italian words "beautiful woman" and the historical use of herb eye-drops by women to dilate the pupils of the eyes for aesthetic purposes. … [DB00572] is a non-selective muscarinic antagonist that is mainly used as an adjunct for anaesthesia.