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Cedazuridine
go.drugbank.com/drugs/DB15694ApprovedInvestigational[A215107, A215112, A215117, A215127, L14897] Cedazuridine was first reported in 2014,[A215107] and was subsequently approved by the FDA on July 7, 2020, in combination with [decitabine] for sale by … [A215127, L14897] Although effective, these compounds are rapidly metabolized by cytidine deaminase (CDA) prior to reaching systemic circulation when administered orally, necessitating intramuscular or
Asparaginase Erwinia chrysanthemi
go.drugbank.com/drugs/DB08886ApprovedInvestigational[A236344] Studies show that substitution of _Erwinia_ asparaginase for _E. coli_-derived asparaginase following an allergic reaction has been safe and effective. … [L149] In June 2021, the recombinant form of asparaginase _Erwinia chrysanthemi_ was approved by the FDA as a component of a chemotherapy regimen to treat acute lymphoblastic leukemia and lymphoblastic
Pibrentasvir
go.drugbank.com/drugs/DB13878ApprovedInvestigationalthree years and older. … As of June 2025, the FDA approved an expanded indication for Mavyret, making it the first and only direct-acting antiviral therapy approved for the treatment of both acute and chronic HCV in patients aged
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic UseTrofinetide
go.drugbank.com/drugs/DB06045Approved[L64112] The European Commission granted marketing authorization on August 24, 2026 for the treatment of neurobehavioral symptoms of Rett syndrome in adults and pediatric patients aged 5 years and older … , making trofinetide the first and only treatment approved for Rett syndrome in the European Union.
Tenofovir disoproxil
go.drugbank.com/drugs/DB00300ApprovedInvestigationalThis drug is prescribed in combination with other drugs for the management of HIV infection as well as for Hepatitis B therapy. Tenofovir disoproxil was initially approved in 2001 [FDA label].
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic UseTropicamide
go.drugbank.com/drugs/DB00809Approved[A229958] It is also used in combination with [hydroxyamphetamine] for the same indication. … [A230103] Usually available in ophthalmic formulations, tropicamide is used to cause mydriasis and cycloplegia for eye exams or ocular procedures.
Aminophylline
go.drugbank.com/drugs/DB01223ApprovedInvestigationalSimilar to other theophyllines, aminophylline is indicated for the treatment of lung diseases such as asthma, chronic bronchitis, and COPD.
Categories: Drugs for Obstructive Airway Diseases, Compounds used in a research, industrial, or household settingSulfamethoxazole
go.drugbank.com/drugs/DB01015ApprovedInvestigational[L11830] In this combination, sulfamethoxazole is useful for the treatment of a variety of bacterial infections, including those of the urinary, respiratory, and gastrointestinal tracts. … which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps in the biosynthesis of nucleic acids and proteins which are necessary for
Mixtures: KEMOPRİM FORT 800/160 TABLET, SEPTRIN FORT TABLET, 20 ADETCategories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseBupropion
go.drugbank.com/drugs/DB01156ApprovedInvestigationalor TCAs, for example. … [A6399,A178810] Bupropion was originally classified as an "atypical" antidepressant because it does not exert the same effects as the classical antidepressants such as Monoamine Oxidase Inhibitors (
Categories: Antidepressive Agents Indicated for DepressionIodide I-123
go.drugbank.com/drugs/DB09420ApprovedInvestigationalRadioactive I-123 in particular is effective for this use as its half-life of approximately 13.13 h (hours) is ideal for the 24-h (hour) iodine uptake test and it has a reduced radiation burden as compared … Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland.