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Filapixant
go.drugbank.com/drugs/DB21467ExperimentalFilapixant is a small molecule drug. The usage of the INN stem '-pixant' in the name indicates that Filapixant is a purinoreceptor (P2X) antagonist. Filapixant has a monoisotopic molecular weight of 521.17 Da.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesSevabertinib
go.drugbank.com/drugs/DB21667ApprovedInvestigationalSevabertinib is a kinase inhibitor indicated for adult patients with locally advanced or metastatic non-squamous non-small cell lung cancer (NSCLC) whose tumors have HER2 (ERBB2) tyrosine kinase domain (TKD) activating mutations. Sevaber...
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesDaraxonrasib
go.drugbank.com/drugs/DB22308ApprovedInvestigationalDaraxonrasib is an orally administered, multi-selective inhibitor of the RAS GTPase family used to treat metastatic pancreatic adenocarcinoma. It is a RAS(ON) tri-complex inhibitor that binds cyclophilin A and targets the active, GTP-bou...
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesInterferon alfa-2a
go.drugbank.com/drugs/DB00034ApprovedInvestigationalWithdrawnInterferon a (human leukocyte protein moiety reduced). A type I interferon consisting of 165 amino acid residues with lysine in position 23. This protein is produced by recombinant DNA technology and resembles interferon secreted by leuk...
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 Enzyme InhibitorsInterferon beta-1a
go.drugbank.com/drugs/DB00060ApprovedInvestigationalHuman interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of...
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 Enzyme InhibitorsInterferon beta-1b
go.drugbank.com/drugs/DB00068ApprovedInvestigationalHuman interferon beta (165 residues), cysteine 17 is substituted with serine. Produced in E. coli, no carbohydrates, MW=18.5kD
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 Enzyme InhibitorsPegvisomant
go.drugbank.com/drugs/DB00082ApprovedInvestigationalPegvisomant is a highly selective growth hormone (GH) receptor antagonist. It is used to treat acromegaly. Unlike dopamine or somatostatin analogs (which inhibit growth hormone secretion), this drug actually blocks the hepatic (GH-mediat...
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersCitrulline
go.drugbank.com/drugs/DB00155InvestigationalNutraceuticalCitrulline is an amino acid. It is made from ornithine and carbamoyl phosphate in one of the central reactions in the urea cycle. It is also produced from arginine as a by-product of the reaction catalyzed by NOS family. Its name is deri...
Vitamin A
go.drugbank.com/drugs/DB00162ApprovedInvestigationalNutraceuticalVet approvedRetinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A i...
Mixtures: Ch-P Cap, P-NATAL®Amphetamine
go.drugbank.com/drugs/DB00182ApprovedIllicitInvestigationalAmphetamine, a compound discovered over 100 years ago, is one of the more restricted controlled drugs. It was previously used for a large variety of conditions and this changed until this point where its use is highly restricted. Ampheta...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 Inhibitors