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Nuclear receptor subfamily 1 group I member 3
go.drugbank.com/bio_entities/BE0003848TargetHumansBinds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes.
Polypeptides: Nuclear receptor subfamily 1 group I member 3Synonyms: Orphan nuclear receptor MB67, Constitutive androstane receptorPeroxisome proliferator-activated receptor gamma coactivator 1-beta
go.drugbank.com/bio_entities/BE0009812TargetHumansActivates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids.
Polypeptides: Peroxisome proliferator-activated receptor gamma coactivator 1-betaSynonyms: PGC-1-related estrogen receptor alpha coactivatorLeukocyte immunoglobulin-like receptor subfamily B member 2
go.drugbank.com/bio_entities/BE0010561TargetHumansReceptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:11169396, PubMed:12853576, PubMed:16455647, PubMed:20448110, PubMed:27859042).
Polypeptides: Leukocyte immunoglobulin-like receptor subfamily B member 2Synonyms: Leukocyte immunoglobulin-like receptor 2, Monocyte/macrophage immunoglobulin-like receptor 10Leukocyte immunoglobulin-like receptor subfamily B member 1
go.drugbank.com/bio_entities/BE0010562TargetHumansReceptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:16455647, PubMed:28636952). … Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response.
Polypeptides: Leukocyte immunoglobulin-like receptor subfamily B member 1Synonyms: Leukocyte immunoglobulin-like receptor 1, Monocyte/macrophage immunoglobulin-like receptor 7Leukocyte immunoglobulin-like receptor subfamily B member 4
go.drugbank.com/bio_entities/BE0017129TargetHumansThis inhibition of monocyte activation occurs at least in part via binding to FN1 (PubMed:34089617). … Receptor for apolipoprotein APOE (PubMed:30333625). Receptor for ALCAM/CD166 (PubMed:29263213).
Polypeptides: Leukocyte immunoglobulin-like receptor subfamily B member 4Synonyms: Monocyte inhibitory receptor HM18, Leukocyte immunoglobulin-like receptor 5Mas-related G protein-coupled receptor member X2
go.drugbank.com/bio_entities/BE0018408TargetHumansLigand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed … Mast cell-specific G protein-coupled receptor for basic secretagogues, which regulates mast cell degranulation and itch-related hypersensitivity reactions (PubMed:22069323, PubMed:25517090, PubMed:28288109
Polypeptides: Mas-related G protein-coupled receptor member X2Function: C-C chemokine receptor activityHexylresorcinol
go.drugbank.com/drugs/DB11254ApprovedHexylresorcinol is a substituted dihydroxybenzene. It exhibits antiseptic, anthelmintic, and local anesthetic properties. It can be found in topical applications for minor skin infections and in oral solutions or throat lozenges for pain...
Triple-Negative Breast Cancer
go.drugbank.com/conditions/DBCOND0068542Drugs: AtezolizumabSynonyms: Breast Carcinoma That is Estrogen Receptor, Progesterone Receptor, and Her2 NegativeBemotrizinol
go.drugbank.com/drugs/DB11206ApprovedBemotrizinol, or bis-ethylhexyloxyphenol methoxyphenyl triazine, is an organic UV filter found in over-the-counter sunscreen products. It primarily absorbs UV-A rays.
Ichthammol
go.drugbank.com/drugs/DB11341ApprovedIt is an ammonium salt of dark sulfonated shale oil (bituminous schists) produced via distillation of the oil followed by sulfonation and neutralization.