Nuclear receptor subfamily 1 group I member 3

BE0003848ProteinHumansNR1I3

Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. It is acted on by 19 drugs in DrugBank.

Gene name
NR1I3
UniProtKB entry
Q14994Swiss-Prot
Cellular location
Nucleus
Residues / weight
352 residues · 39,942 Da
Also known as
CAR · Constitutive activator of retinoid response · Constitutive active response · Constitutive androstane receptor · Orphan nuclear receptor MB67

Resolves to

Protein
UniProtQ14994UniProt nameNR1I3_HUMAN
Gene
HGNCHGNC:7969NCBI Gene9970GenBank458542GeneCardsNR1I3
Pharmacology
IUPHAR/GtoPdb607KEGGhsa:9970
Structure
PDB1XV9PDB1XVP
Drugs

What you can answer from here — as of September 07, 2019

19DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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11GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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32+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Nuclear receptor subfamily 1 group I member 3, how selective are they, and which programs against it are still in active trials?

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