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Displaying results 1281 - 1290 of 10000 in total
  1. Drug

    SY-5609

    go.drugbank.com/drugs/DB17099
    Investigational

    Synonyms: (S)-7-(dimethylphosphoryl)-3-(2-((6,6-dimethylpiperidin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)-1H-indole-6-carbonitrile, 1H-Indole-6-carbonitrile, 7-(dimethylphosphinyl)-3-[2-[[(3S)-6,6-dimethyl-3-piperidinyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]-Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-Ring
  2. Drug

    Unesbulin

    go.drugbank.com/drugs/DB18080
    Investigational

    Synonyms: 4,6-pyrimidinediamine, 5-fluoro-2-(6-fluoro-2-methyl-1h-benzimidazol-1-yl)-n4-(4-(trifluoromethyl)phenyl)-, 5-fluoro-2-(6-fluoro-2-methyl-1h-benzimidazol-1-yl)-n4-(4-(trifluoromethyl)phenyl)-4,6-pyrimidinediamineCategories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-Ring
  3. Drug

    Revumenib

    go.drugbank.com/drugs/DB18515
    ApprovedInvestigational

    [L51888] In October of 20225, it was approved for myeloid leukemia patients with nucleophosmin 1 (NPM1) mutations. [L54376] … Abnormal gene rearrangements at chromosome locus 11q23, called KMT2A rearrangements or translocations, are present in 5%-10% of patients with acute leukemias and are the sole genetic aberration found in

    Synonyms: Benzamide, n-ethyl-2-((4-(7-((trans-4-((ethylsulfonyl)amino)cyclohexyl)methyl)-2,7-diazaspiro(3.5)non-2-yl)-5-pyrimidinyl)oxy)-5-fluoro-n-(1-methylethyl)-Categories: MATE 1 Inhibitors, MATE 1 Substrates
  4. Drug

    Hydralazine

    go.drugbank.com/drugs/DB01275
    ApprovedInvestigational

    Originally developed in the 1950s as a malaria treatment, hydralazine showed antihypertensive ability and was soon repurposed. … [A186841] Hydralazine is a hydrazine derivative vasodilator used alone or as adjunct therapy in the treatment of hypertension and only as adjunct therapy in the treatment of heart failure.

    Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP3A InhibitorsSynonyms: 6-Hydralazine, 1-Hydrazinophthalazine
  5. Drug

    3-{[(5R,6R)-5-Benzyl-6-hydroxy-2,4-bis(4-hydroxybenzyl)-3-oxo-1,2,4-triazepan-1-yl]sulfonyl}benzonitril

    go.drugbank.com/drugs/DB03141
    Experimental

    Synonyms: 3-{[(5R,6R)-5-Benzyl-6-hydroxy-2,4-bis(4-hydroxybenzyl)-3-oxo-1,2,4-triazepan-1-yl]sulfonyl}benzonitril
  6. Drug

    Bleximenib

    go.drugbank.com/drugs/DB19328
    Investigational

    Bleximenib is under investigation in clinical trials NCT04811560 (A Phase 1/2 Study of Bleximenib in Participants With Acute Leukemia) and NCT05453903 (A Study of Bleximenib in Combination With Acute Myeloid

    Synonyms: Benzamide, N-ethyl-5-fluoro-2-[[5-[2-[(1R)-4-[(2-methoxyethyl)methylamino]-1-(1-methylethyl)butyl]-2,6-diazaspiro[3.4]oct-6-yl]-1,2,4-triazin-6-yl]oxy]-N-(1-methylethyl)-, N-ethyl-5-fluoro-2-{[5-(2-{(3R)-6-[(2-methoxyethyl)(methyl)amino]-2-methylhexan-3-yl}-2,6-diazaspiro[3.4]octan-6-yl)-1,2,4-triazin-6-yl]oxy}-N-(propan-2-yl)benzamide
  7. Drug

    Padnarsertib

    go.drugbank.com/drugs/DB19243
    Investigational

    Synonyms: 2-propenamide, 3-(6-amino-3-pyridinyl)-n-((5-(4-((4,4-difluoro-1-piperidinyl)carbonyl)phenyl)-7-(4-fluorophenyl)-2-benzofuranyl)methyl)-, (2e)-, Pak4-in-1Categories: Heterocyclic Compounds, 1-Ring
  8. Drug

    9-(2-Deoxy-Beta-D-Ribofuranosyl)-6-Methylpurine

    go.drugbank.com/drugs/DB03735
    Experimental

    Synonyms: 9-(2-Deoxy-Beta-D-Ribofuranosyl)-6-Methylpurine
  9. Drug

    6-(Oxalyl-Amino)-1h-Indole-5-Carboxylic Acid

    go.drugbank.com/drugs/DB04001
    Experimental

    Synonyms: 6-(Oxalyl-Amino)-1h-Indole-5-Carboxylic Acid
  10. Drug

    5-Heptyl-6-hydroxy-1,3-benzothiazole-4,7-dione

    go.drugbank.com/drugs/DB07636
    Experimental

    Synonyms: 5-Heptyl-6-hydroxy-1,3-benzothiazole-4,7-dione